{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Keuler T"],"funding":["Studienstiftung des Deutschen Volkes","Deutsche Forschungsgemeinschaft","J?rgen Manchot Stiftung"],"pagination":["8158-8162"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8908490"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(9)"],"pubmed_abstract":["In recent drug development efforts, particular emphasis has been devoted to the chemical interference with the NLRP3 inflammasome. A series of 12 tailored sulfonylureas was designed, prepared through convergent syntheses with a final sodium hydride-promoted reaction of isocyanates and sulfonamides, and subjected to a systematic, high-performance liquid chromatography-based survey of the chemical stability, a critical issue of sulfonylureas in terms of preparation, storage, and application. NLRP3 binding was determined by surface plasmon resonance spectroscopy. Sulfonylurea <b>2</b> was identified to be equipotent and similarly stable compared to the prototypical NLRP3 inhibitor MCC950."],"journal":["ACS omega"],"pubmed_title":["Structure-Stability Relationship of NLRP3 Inflammasome-Inhibiting Sulfonylureas."],"pmcid":["PMC8908490"],"funding_grant_id":["EXC2151 390873048"],"pubmed_authors":["Gutschow M","Keuler T","Ferber D","Marleaux M","Geyer M"],"additional_accession":[]},"is_claimable":false,"name":"Structure-Stability Relationship of NLRP3 Inflammasome-Inhibiting Sulfonylureas.","description":"In recent drug development efforts, particular emphasis has been devoted to the chemical interference with the NLRP3 inflammasome. A series of 12 tailored sulfonylureas was designed, prepared through convergent syntheses with a final sodium hydride-promoted reaction of isocyanates and sulfonamides, and subjected to a systematic, high-performance liquid chromatography-based survey of the chemical stability, a critical issue of sulfonylureas in terms of preparation, storage, and application. NLRP3 binding was determined by surface plasmon resonance spectroscopy. Sulfonylurea <b>2</b> was identified to be equipotent and similarly stable compared to the prototypical NLRP3 inhibitor MCC950.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-26T04:34:31.534Z","creation":"2025-04-06T11:14:18.494Z"},"accession":"S-EPMC8908490","cross_references":{"pubmed":["35284735"],"doi":["10.1021/acsomega.2c00125"]}}