{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(4)"],"submitter":["Ding Y"],"pubmed_abstract":["Hepatocellular carcinoma (HCC) is the most common malignant liver tumor with high mortality and poor prognosis worldwide. This study aimed to identify hub genes and investigate the underlying molecular mechanisms in HCC progression by integrated bioinformatics analysis and experimental validation. Based on the Gene Expression Omnibus (GEO) databases and The Cancer Genome Atlas (TCGA), 12 critical differential co-expression genes were identified between tumor and normal tissues. Via survival analysis, we found higher expression of LCAT, ACSM3, IGF1, SRD5A2, THRSP and ACADS was associated with better prognoses in HCC patients. Among which, THRSP was selected for the next investigations. We found that THRSP mRNA expression was negatively correlated with its methylation and closely associated "],"journal":["Aging"],"pagination":["1743-1766"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8908915"],"repository":["biostudies-literature"],"pubmed_title":["THRSP identified as a potential hepatocellular carcinoma marker by integrated bioinformatics analysis and experimental validation."],"pmcid":["PMC8908915"],"pubmed_authors":["Liu X","Deng C","Sheng Y","Ding Y","Li D","Sun C","Ojha SC","Yuan Y"],"additional_accession":[]},"is_claimable":false,"name":"THRSP identified as a potential hepatocellular carcinoma marker by integrated bioinformatics analysis and experimental validation.","description":"Hepatocellular carcinoma (HCC) is the most common malignant liver tumor with high mortality and poor prognosis worldwide. This study aimed to identify hub genes and investigate the underlying molecular mechanisms in HCC progression by integrated bioinformatics analysis and experimental validation. Based on the Gene Expression Omnibus (GEO) databases and The Cancer Genome Atlas (TCGA), 12 critical differential co-expression genes were identified between tumor and normal tissues. Via survival analysis, we found higher expression of LCAT, ACSM3, IGF1, SRD5A2, THRSP and ACADS was associated with better prognoses in HCC patients. Among which, THRSP was selected for the next investigations. We found that THRSP mRNA expression was negatively correlated with its methylation and closely associated ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-19T21:45:36.67Z","creation":"2025-04-19T21:45:36.67Z"},"accession":"S-EPMC8908915","cross_references":{"pubmed":["35196258"],"doi":["10.18632/aging.203900"]}}