{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(4)"],"submitter":["Cao H"],"pubmed_abstract":["Tumor-associated macrophages (TAMs) are critical immune cells infiltrated into tumor. In present study, we evaluated the effects of Qi Ling (QL), a traditional Chinese medicine on paclitaxel resistance in prostate cancer cells and explored the underlying mechanisms. We administrated QL to rats and collected the serum from QL-treated rats (QL-serum). We established the co-culture system of TAMs/paclitaxel resistant prostate cancer cells. We treated the TAMs with QL-serum and measured the viability of paclitaxel resistant prostate cancer cells after exposing to paclitaxel. We monitored the expression of M1 and M2 markers, the expression and activation of IL-6/STAT3 signaling pathways in TAMs after QL treatment. We treated TAMs with QL-serum together with interleukin (IL)-6, measured the expr"],"journal":["Aging"],"pagination":["1812-1821"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8908933"],"repository":["biostudies-literature"],"pubmed_title":["Qi Ling decreases paclitaxel resistance in the human prostate cancer by reversing tumor-associated macrophages function."],"pmcid":["PMC8908933"],"pubmed_authors":["Gao R","Cao H","Wang D","Feng Y","Chen L"],"additional_accession":[]},"is_claimable":false,"name":"Qi Ling decreases paclitaxel resistance in the human prostate cancer by reversing tumor-associated macrophages function.","description":"Tumor-associated macrophages (TAMs) are critical immune cells infiltrated into tumor. In present study, we evaluated the effects of Qi Ling (QL), a traditional Chinese medicine on paclitaxel resistance in prostate cancer cells and explored the underlying mechanisms. We administrated QL to rats and collected the serum from QL-treated rats (QL-serum). We established the co-culture system of TAMs/paclitaxel resistant prostate cancer cells. We treated the TAMs with QL-serum and measured the viability of paclitaxel resistant prostate cancer cells after exposing to paclitaxel. We monitored the expression of M1 and M2 markers, the expression and activation of IL-6/STAT3 signaling pathways in TAMs after QL treatment. We treated TAMs with QL-serum together with interleukin (IL)-6, measured the expr","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-26T04:49:22.766Z","creation":"2025-04-06T11:14:17.165Z"},"accession":"S-EPMC8908933","cross_references":{"pubmed":["35193986"],"doi":["10.18632/aging.203904"]}}