{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pham K"],"funding":["National Institute of Neurological Disorders and Stroke","National Cancer Institute","NCI NIH HHS","NINDS NIH HHS"],"pagination":["1311"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8909278"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(5)"],"pubmed_abstract":["Reprograming of cellular metabolism is a hallmark of cancer. Altering metabolism allows cancer cells to overcome unfavorable microenvironment conditions and to proliferate and invade. Medulloblastoma is the most common malignant brain tumor of children. Genomic amplification of <i>MYC</i> defines a subset of poor-prognosis medulloblastoma. We performed comprehensive metabolic studies of human <i>MYC</i>-amplified medulloblastoma by comparing the metabolic profiles of tumor cells in three different conditions-in vitro, in flank xenografts and in orthotopic xenografts in the cerebellum. Principal component analysis showed that the metabolic profiles of brain and flank high-MYC medulloblastoma tumors clustered closely together and separated away from normal brain and in vitro MYC-amplified ce"],"journal":["Cancers"],"pubmed_title":["Comprehensive Metabolic Profiling of MYC-Amplified Medulloblastoma Tumors Reveals Key Dependencies on Amino Acid, Tricarboxylic Acid and Hexosamine Pathways."],"pmcid":["PMC8909278"],"funding_grant_id":["P30CA006973","R01 NS103927","1R01NS103927","T32 CA193145"],"pubmed_authors":["Hanaford AR","Parthasarathy A","Slusher BS","Pham K","Alt J","Raabe EH","Poore BA","Sweeney H","Rais R","Eberhart CG","Maxwell MJ"],"additional_accession":[]},"is_claimable":false,"name":"Comprehensive Metabolic Profiling of MYC-Amplified Medulloblastoma Tumors Reveals Key Dependencies on Amino Acid, Tricarboxylic Acid and Hexosamine Pathways.","description":"Reprograming of cellular metabolism is a hallmark of cancer. Altering metabolism allows cancer cells to overcome unfavorable microenvironment conditions and to proliferate and invade. Medulloblastoma is the most common malignant brain tumor of children. Genomic amplification of <i>MYC</i> defines a subset of poor-prognosis medulloblastoma. We performed comprehensive metabolic studies of human <i>MYC</i>-amplified medulloblastoma by comparing the metabolic profiles of tumor cells in three different conditions-in vitro, in flank xenografts and in orthotopic xenografts in the cerebellum. Principal component analysis showed that the metabolic profiles of brain and flank high-MYC medulloblastoma tumors clustered closely together and separated away from normal brain and in vitro MYC-amplified ce","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T12:56:45.384Z","creation":"2025-04-04T12:56:45.384Z"},"accession":"S-EPMC8909278","cross_references":{"pubmed":["35267619"],"doi":["10.3390/cancers14051311"]}}