{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yan Z"],"funding":["American Heart Association","National Institutes of Health"],"pagination":["779"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8909652"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(5)"],"pubmed_abstract":["Background The impairment of the inner blood-retinal barrier (iBRB) increases the pathological development of diabetic retinopathy (DR), a severe complication in diabetic patients. Identifying approaches to preserving iBRB integrity and function is a significant challenge in DR. C1q/tumor necrosis factor-related protein-3 (CTRP3) is a newly discovered adipokine and a vital biomarker, predicting DR severity. We sought to determine whether and how CTRP3 affects the pathological development of non-proliferative diabetic retinopathy (NPDR). Methods To clarify the pathophysiologic progress of the blood-retinal barrier in NPDR and explore its potential mechanism, a mouse Type 2 diabetic model of diabetic retinopathy was used. The capillary leakage was assessed by confocal microscope with fluores"],"journal":["Cells"],"pubmed_title":["C1q/TNF-Related Protein 3 Prevents Diabetic Retinopathy via AMPK-Dependent Stabilization of Blood-Retinal Barrier Tight Junctions."],"pmcid":["PMC8909652"],"funding_grant_id":["TPA","96686"],"pubmed_authors":["Liu J","Naik UP","Wang C","Ma X","Meng Z","Guo R","Xie D","Christopher TA","Yan Z","Gan L","Bond Lau W","Lopez BL","Wang Y","Zhao J"],"additional_accession":[]},"is_claimable":false,"name":"C1q/TNF-Related Protein 3 Prevents Diabetic Retinopathy via AMPK-Dependent Stabilization of Blood-Retinal Barrier Tight Junctions.","description":"Background The impairment of the inner blood-retinal barrier (iBRB) increases the pathological development of diabetic retinopathy (DR), a severe complication in diabetic patients. Identifying approaches to preserving iBRB integrity and function is a significant challenge in DR. C1q/tumor necrosis factor-related protein-3 (CTRP3) is a newly discovered adipokine and a vital biomarker, predicting DR severity. We sought to determine whether and how CTRP3 affects the pathological development of non-proliferative diabetic retinopathy (NPDR). Methods To clarify the pathophysiologic progress of the blood-retinal barrier in NPDR and explore its potential mechanism, a mouse Type 2 diabetic model of diabetic retinopathy was used. The capillary leakage was assessed by confocal microscope with fluores","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-05-18T12:07:35.511Z","creation":"2025-05-18T12:07:35.511Z"},"accession":"S-EPMC8909652","cross_references":{"pubmed":["35269401"],"doi":["10.3390/cells11050779"]}}