{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang HN"],"funding":["Natural Science Foundation of Shenzhen City","Natural Science Foundation of Guangdong Province","National Natural Science Foundation of China"],"pagination":["1577"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8912031"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(5)"],"pubmed_abstract":["Mast cells (MCs) are an important treatment target for high-affinity IgE Fc receptor (FcεRI)-mediated allergic diseases. The plant-derived molecule 4-methylumbelliferone (4-MU) has beneficial effects in animal models of inflammation and autoimmunity diseases. The aim of this study was to examine 4-MU effects on MC activation and probe the underlying molecular mechanism(s). We sensitized rat basophilic leukemia cells (RBLs) and mouse bone marrow-derived mast cells (BMMCs) with anti-dinitrophenol (DNP) immunoglobulin (Ig)E antibodies, stimulated them with exposure to DNP-human serum albumin (HSA), and then treated stimulated cells with 4-MU. Signaling-protein expression was determined by immunoblotting. In vivo allergic responses were examined in IgE-mediated passive cutaneous anaphylaxis (P"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Plant-Derived Molecule 4-Methylumbelliferone Suppresses FcεRI-Mediated Mast Cell Activation and Allergic Inflammation."],"pmcid":["PMC8912031"],"funding_grant_id":["2021A1515011140","JCYJ20210324095004012 and JCYJ20190808155603545","82071806"],"pubmed_authors":["Wang HN","Zhao ZF","Yue XN","Lin HH","Guo WJ","Ji K","Chen JJ","Chen JN","Xiang QA","Guo WM"],"additional_accession":[]},"is_claimable":false,"name":"Plant-Derived Molecule 4-Methylumbelliferone Suppresses FcεRI-Mediated Mast Cell Activation and Allergic Inflammation.","description":"Mast cells (MCs) are an important treatment target for high-affinity IgE Fc receptor (FcεRI)-mediated allergic diseases. The plant-derived molecule 4-methylumbelliferone (4-MU) has beneficial effects in animal models of inflammation and autoimmunity diseases. The aim of this study was to examine 4-MU effects on MC activation and probe the underlying molecular mechanism(s). We sensitized rat basophilic leukemia cells (RBLs) and mouse bone marrow-derived mast cells (BMMCs) with anti-dinitrophenol (DNP) immunoglobulin (Ig)E antibodies, stimulated them with exposure to DNP-human serum albumin (HSA), and then treated stimulated cells with 4-MU. Signaling-protein expression was determined by immunoblotting. In vivo allergic responses were examined in IgE-mediated passive cutaneous anaphylaxis (P","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-22T19:07:52.17Z","creation":"2025-04-06T02:40:45.386Z"},"accession":"S-EPMC8912031","cross_references":{"pubmed":["35268679"],"doi":["10.3390/molecules27051577"]}}