biostudies-literatureBarrett PMVetenskapsrådetHealth Research BoardWellcome Truste0264992https://www.ebi.ac.uk/biostudies/studies/S-EPMC8912264biostudies-literatureUnknown17(3)<h4>Background</h4>Gestational diabetes (GDM) is associated with increased risk of type 2 diabetes (T2DM) and cardiovascular disease. It is uncertain whether GDM is independently associated with the risk of chronic kidney disease. The aim was to examine the association between GDM and maternal CKD and end-stage kidney disease (ESKD) and to determine whether this depends on progression to overt T2DM.<h4>Methods</h4>A population-based cohort study was designed using Swedish national registry data. Previous GDM diagnosis was the main exposure, and this was stratified according to whether women developed T2DM after pregnancy. Using Cox regression models, we estimated the risk of CKD (stages 3-5), ESKD and different CKD subtypes (tubulointerstitial, glomerular, hypertensive, diabetic, other).<hPloS oneDoes gestational diabetes increase the risk of maternal kidney disease? A Swedish national cohort study.PMC89122642009-1068203930/B/16/Z2018-00932Kublickiene KPerry IJMcCarthy FPEvans MBarrett PMStenvinkel PKhashan ASKublickas MfalseDoes gestational diabetes increase the risk of maternal kidney disease? A Swedish national cohort study.<h4>Background</h4>Gestational diabetes (GDM) is associated with increased risk of type 2 diabetes (T2DM) and cardiovascular disease. It is uncertain whether GDM is independently associated with the risk of chronic kidney disease. The aim was to examine the association between GDM and maternal CKD and end-stage kidney disease (ESKD) and to determine whether this depends on progression to overt T2DM.<h4>Methods</h4>A population-based cohort study was designed using Swedish national registry data. Previous GDM diagnosis was the main exposure, and this was stratified according to whether women developed T2DM after pregnancy. Using Cox regression models, we estimated the risk of CKD (stages 3-5), ESKD and different CKD subtypes (tubulointerstitial, glomerular, hypertensive, diabetic, other).<h2022-01-01T00:00:00Z20222025-04-19T00:52:24.569Z2025-04-07T11:47:10.388ZS-EPMC89122643527165010.1371/journal.pone.0264992