{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shi Z"],"funding":["NICHD NIH HHS","NIDDK NIH HHS","NIA NIH HHS","FIC NIH HHS","NHLBI NIH HHS"],"pagination":["1060"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8912709"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(5)"],"pubmed_abstract":["This study focused on identifying whether exposure to the Chinese Great Famine (1959-1961) in early life amplified the potential for fractures in adulthood. The survey was conducted using data from the 1997-2015 China Health and Nutrition Survey (CHNS)-5235 adults born between 1954 and 1964 were selected as the sample size. Fracture was defined based on self-report. Those born from 1962-1964 were treated as non-exposure group. Those with exposure to famine were divided into four subgroups: Fetal, early childhood, mid-childhood, and late childhood cohorts. The association between the groups and fracture was determined using Cox regression. In follow-up data (mean of 11 years), fractures were identified in 418 of the participants. The incidence of fracture was 8.7 in late childhood, 8.1 in mid-childhood, 8.3 in early childhood, 7.0 in fetal, and 5.4 in non-exposed cohorts per 1000 person-year. Compared with the non-exposed group, the famine-exposed groups had an increased risk of developing fracture in adulthood with hazard ratio (HR) and 95% CI of 1.29 (0.90-1.85), 1.48 (1.08-2.03), 1.45 (1.02-2.06), and 1.54 (1.08-2.20), respectively. The positive link of famine exposure to risk of fracture occurred primarily in those participants with a modern diet who lived in urban areas. In conclusion, the risk of fracture in Chinese adults is associated with famine exposure."],"journal":["Nutrients"],"pubmed_title":["Exposure to Chinese Famine during Early Life Increases the Risk of Fracture during Adulthood."],"pmcid":["PMC8912709"],"funding_grant_id":["R01 HD030880","D43 TW009077","R01 DK104371","R01 HL108427","R01 AG065357"],"pubmed_authors":["Yan AF","Shi Z","Shi X"],"additional_accession":[]},"is_claimable":false,"name":"Exposure to Chinese Famine during Early Life Increases the Risk of Fracture during Adulthood.","description":"This study focused on identifying whether exposure to the Chinese Great Famine (1959-1961) in early life amplified the potential for fractures in adulthood. The survey was conducted using data from the 1997-2015 China Health and Nutrition Survey (CHNS)-5235 adults born between 1954 and 1964 were selected as the sample size. Fracture was defined based on self-report. Those born from 1962-1964 were treated as non-exposure group. Those with exposure to famine were divided into four subgroups: Fetal, early childhood, mid-childhood, and late childhood cohorts. The association between the groups and fracture was determined using Cox regression. In follow-up data (mean of 11 years), fractures were identified in 418 of the participants. The incidence of fracture was 8.7 in late childhood, 8.1 in mid-childhood, 8.3 in early childhood, 7.0 in fetal, and 5.4 in non-exposed cohorts per 1000 person-year. Compared with the non-exposed group, the famine-exposed groups had an increased risk of developing fracture in adulthood with hazard ratio (HR) and 95% CI of 1.29 (0.90-1.85), 1.48 (1.08-2.03), 1.45 (1.02-2.06), and 1.54 (1.08-2.20), respectively. The positive link of famine exposure to risk of fracture occurred primarily in those participants with a modern diet who lived in urban areas. In conclusion, the risk of fracture in Chinese adults is associated with famine exposure.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2024-11-08T15:36:59.253Z","creation":"2024-11-08T15:36:59.253Z"},"accession":"S-EPMC8912709","cross_references":{"pubmed":["35268035"],"doi":["10.3390/nu14051060"]}}