biostudies-literatureSanchez EDiputació de Lleida and Generalitat de Catalunya1102https://www.ebi.ac.uk/biostudies/studies/S-EPMC8912766biostudies-literatureUnknown14(5)A large body of evidence demonstrates a relationship between hyperglycemia and increased concentrations of advanced glycation end-products (AGEs). However, there is little information about subcutaneous AGE accumulation in subjects with prediabetes, and whether or not this measurement could assist in the diagnosis of prediabetes is unclear. A cross-sectional study was conducted in 4181 middle-aged subjects without diabetes. Prediabetes (n = 1444) was defined as a glycosylated hemoglobin (HbA1c) level between 39 and 47 mmol/mol (5.7 to 6.4%), and skin autofluorescence (SAF) measurement was performed to assess AGEs. A multivariable logistic regression model and receiver operating characteristic curve were used. The cohort consisted of 50.1% women with an age of 57 [52;62] years, a BMI of 28.NutrientsWeak Association between Skin Autofluorescence Levels and Prediabetes with an ILERVAS Cross-Sectional Study.PMC89127662017SGR696 and SLT0021600250Sauret ACastro-Boque EGavalda RTorres GHernandez MFernandez EPamplona RFarras-Salles CBermudez-Lopez MPurroy FGodoy PRius FLecube AMauricio DButi MSanchez EKerkeni MfalseWeak Association between Skin Autofluorescence Levels and Prediabetes with an ILERVAS Cross-Sectional Study.A large body of evidence demonstrates a relationship between hyperglycemia and increased concentrations of advanced glycation end-products (AGEs). However, there is little information about subcutaneous AGE accumulation in subjects with prediabetes, and whether or not this measurement could assist in the diagnosis of prediabetes is unclear. A cross-sectional study was conducted in 4181 middle-aged subjects without diabetes. Prediabetes (n = 1444) was defined as a glycosylated hemoglobin (HbA1c) level between 39 and 47 mmol/mol (5.7 to 6.4%), and skin autofluorescence (SAF) measurement was performed to assess AGEs. A multivariable logistic regression model and receiver operating characteristic curve were used. The cohort consisted of 50.1% women with an age of 57 [52;62] years, a BMI of 28.2022-01-01T00:00:00Z2022 Mar2025-04-18T12:12:13.884Z2025-04-06T21:48:13.838ZS-EPMC89127663526807510.3390/nu14051102