{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Shim S"],"funding":["National Research Foundation of Korea","Korea Food Research Institute"],"pubmed_abstract":["IL-32 plays a contradictory role such as tumor proliferation or suppressor in cancer development depending on the cancer type. In most cancers, it was found that the high expression of IL-32 was associated with more proliferative and progression of cancer. However, studying the isoforms of IL-32 cytokine has placed its paradoxical role into a wide range of functions based on its dominant isoform and surrounding environment. IL-32β, for example, was found mostly in different types of cancer and associated with cancer expansion. This observation is legitimate since cancer exhibits some hypoxic environment and IL-32β was known to be induced under hypoxic conditions. However, IL-32θ interacts directly with protein kinase C-δ reducing NF-κB and STAT3 levels to inhibit epithelial-mesenchymal tra"],"journal":["Frontiers in immunology"],"pagination":["837590"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8913503"],"repository":["biostudies-literature"],"pubmed_title":["A Paradoxical Effect of Interleukin-32 Isoforms on Cancer."],"pmcid":["PMC8913503"],"pubmed_authors":["Shim S","Lee S","Kim SY","Jhun H","Kim YG","Hwang J","Kim S","Nguyen TT","Yeom SC","Taitt AS","Park HY","Lee Y","Hisham Y"],"additional_accession":[]},"is_claimable":false,"name":"A Paradoxical Effect of Interleukin-32 Isoforms on Cancer.","description":"IL-32 plays a contradictory role such as tumor proliferation or suppressor in cancer development depending on the cancer type. In most cancers, it was found that the high expression of IL-32 was associated with more proliferative and progression of cancer. However, studying the isoforms of IL-32 cytokine has placed its paradoxical role into a wide range of functions based on its dominant isoform and surrounding environment. IL-32β, for example, was found mostly in different types of cancer and associated with cancer expansion. This observation is legitimate since cancer exhibits some hypoxic environment and IL-32β was known to be induced under hypoxic conditions. However, IL-32θ interacts directly with protein kinase C-δ reducing NF-κB and STAT3 levels to inhibit epithelial-mesenchymal tra","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T07:55:05.291Z","creation":"2025-04-04T07:55:05.291Z"},"accession":"S-EPMC8913503","cross_references":{"pubmed":["35281008"],"doi":["10.3389/fimmu.2022.837590"]}}