{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Szlaga A"],"funding":["Uniwersytet Jagielloński w Krakowie","Narodowe Centrum Nauki"],"pubmed_abstract":["The medial septum (MS) is critically involved in theta rhythmogenesis and control of the hippocampal network, with which it is reciprocally connected. MS activity is influenced by brainstem structures, including the stress-sensitive, nucleus incertus (NI), the main source of the neuropeptide relaxin-3 (RLN3). In the current study, we conducted a comprehensive neurochemical and electrophysiological characterization of NI neurons innervating the MS in the rat, by employing classical and viral-based neural tract-tracing and electrophysiological approaches, and multiplex fluorescent <i>in situ</i> hybridization. We confirmed earlier reports that the MS is innervated by RLN3 NI neurons and documented putative glutamatergic (vGlut2 mRNA-expressing) neurons as a relevant NI neuronal population wi"],"journal":["Frontiers in cellular neuroscience"],"pagination":["836116"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8913896"],"repository":["biostudies-literature"],"pubmed_title":["Functional Neuroanatomy of the Rat Nucleus Incertus-Medial Septum Tract: Implications for the Cell-Specific Control of the Septohippocampal Pathway."],"pmcid":["PMC8913896"],"pubmed_authors":["Gugula A","Trenk A","Drwiega G","Ma S","Singleton CE","Gundlach AL","Blasiak T","Blasiak A","Szlaga A","Sambak P"],"additional_accession":[]},"is_claimable":false,"name":"Functional Neuroanatomy of the Rat Nucleus Incertus-Medial Septum Tract: Implications for the Cell-Specific Control of the Septohippocampal Pathway.","description":"The medial septum (MS) is critically involved in theta rhythmogenesis and control of the hippocampal network, with which it is reciprocally connected. MS activity is influenced by brainstem structures, including the stress-sensitive, nucleus incertus (NI), the main source of the neuropeptide relaxin-3 (RLN3). In the current study, we conducted a comprehensive neurochemical and electrophysiological characterization of NI neurons innervating the MS in the rat, by employing classical and viral-based neural tract-tracing and electrophysiological approaches, and multiplex fluorescent <i>in situ</i> hybridization. We confirmed earlier reports that the MS is innervated by RLN3 NI neurons and documented putative glutamatergic (vGlut2 mRNA-expressing) neurons as a relevant NI neuronal population wi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T20:51:00.045Z","creation":"2025-04-04T20:51:00.045Z"},"accession":"S-EPMC8913896","cross_references":{"pubmed":["35281300"],"doi":["10.3389/fncel.2022.836116"]}}