biostudies-literatureUnknown9Francisco-Pascual J<h4>Objective</h4>To analyze if there are sex-related differences in patients with unexplained syncope and bundle branch block (BBB).<h4>Background</h4>Despite increasing awareness that sex is a major determinant of the incidence, etiology, and the outcomes of different arrhythmias, no studies have examined differences in presentation and outcomes between men and women with syncope and BBB.<h4>Methods</h4>Cohort study of consecutive patients with unexplained syncope and BBB was included from January 2010 to January 2021 with a median follow-up time of 3.4 years [interquartile range (IQR) 1.7-6.0 years]. They were evaluated by a stepwise workup protocol based on electrophysiological study (EPS) and long-term follow-up with an implantable cardiac monitor (ICM).<h4>Results</h4>Of the 443 patiFrontiers in cardiovascular medicine838473https://www.ebi.ac.uk/biostudies/studies/S-EPMC8914040biostudies-literatureSex-Related Differences in Patients With Unexplained Syncope and Bundle Branch Block: Lower Risk of AV Block and Lesser Need for Cardiac Pacing in Women.PMC8914040Pascual-Gonzalez GBadia-Molins CFrancisco-Pascual JRoca-Luque ISambola-Ayala ABenito BMoya-Mitjans ACantalapiedra-Romero JRivas-Gandara NBach-Oller MFerreira-Gonzalez ISantos-Ortega AMaymi-Ballesteros MRodriguez-Silva JPerez-Rodon JfalseSex-Related Differences in Patients With Unexplained Syncope and Bundle Branch Block: Lower Risk of AV Block and Lesser Need for Cardiac Pacing in Women.<h4>Objective</h4>To analyze if there are sex-related differences in patients with unexplained syncope and bundle branch block (BBB).<h4>Background</h4>Despite increasing awareness that sex is a major determinant of the incidence, etiology, and the outcomes of different arrhythmias, no studies have examined differences in presentation and outcomes between men and women with syncope and BBB.<h4>Methods</h4>Cohort study of consecutive patients with unexplained syncope and BBB was included from January 2010 to January 2021 with a median follow-up time of 3.4 years [interquartile range (IQR) 1.7-6.0 years]. They were evaluated by a stepwise workup protocol based on electrophysiological study (EPS) and long-term follow-up with an implantable cardiac monitor (ICM).<h4>Results</h4>Of the 443 pati2022-01-01T00:00:00Z20222025-04-21T23:09:59.887Z2025-04-05T19:06:52.076ZS-EPMC89140403528238410.3389/fcvm.2022.838473