{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hafeez S"],"funding":["European Research Council","Province of Limburg"],"pagination":["4057-4070"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8915260"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["144(9)"],"pubmed_abstract":["Supramolecular materials based on the self-assembly of benzene-1,3,5-tricarboxamide (BTA) offer an approach to mimic fibrous self-assembled proteins found in numerous natural systems. Yet, synthetic methods to rapidly build complexity, scalability, and multifunctionality into BTA-based materials are needed. The diversity of BTA structures is often hampered by the limited flexibility of existing desymmetrization routes and the purification of multifunctional BTAs. To alleviate this bottleneck, we have developed a desymmetrization method based on activated ester coupling of a symmetric synthon. We created a small library of activated ester synthons and found that a pentafluorophenol benzene triester (BTE) enabled effective desymmetrization and creation of multifunctional BTAs in good yield w"],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Desymmetrization via Activated Esters Enables Rapid Synthesis of Multifunctional Benzene-1,3,5-tricarboxamides and Creation of Supramolecular Hydrogelators."],"pmcid":["PMC8915260"],"funding_grant_id":["694801"],"pubmed_authors":["Duimel H","Suylen D","van Blitterswijk C","Hackeng TM","Baker MB","Ooi HW","Hafeez S"],"additional_accession":[]},"is_claimable":false,"name":"Desymmetrization via Activated Esters Enables Rapid Synthesis of Multifunctional Benzene-1,3,5-tricarboxamides and Creation of Supramolecular Hydrogelators.","description":"Supramolecular materials based on the self-assembly of benzene-1,3,5-tricarboxamide (BTA) offer an approach to mimic fibrous self-assembled proteins found in numerous natural systems. Yet, synthetic methods to rapidly build complexity, scalability, and multifunctionality into BTA-based materials are needed. The diversity of BTA structures is often hampered by the limited flexibility of existing desymmetrization routes and the purification of multifunctional BTAs. To alleviate this bottleneck, we have developed a desymmetrization method based on activated ester coupling of a symmetric synthon. We created a small library of activated ester synthons and found that a pentafluorophenol benzene triester (BTE) enabled effective desymmetrization and creation of multifunctional BTAs in good yield w","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-18T20:25:45.405Z","creation":"2025-04-07T08:25:13.25Z"},"accession":"S-EPMC8915260","cross_references":{"pubmed":["35196454"],"doi":["10.1021/jacs.1c12685"]}}