biostudies-literatureYu JNatural Science Foundation of ChinaMinistry of Science and Technology of the People&apos;s Republic of Chinathe Chinese Preventive Medicine AssociationSanofi PasteurNational Natural Science Foundation of Chinae053316https://www.ebi.ac.uk/biostudies/studies/S-EPMC8915282biostudies-literatureUnknown12(3)<h4>Introduction</h4>Pertussis is one of the top 10 diseases of children under 10 years of age, and the few vaccine-preventable diseases who is on a rise in China in recent years; however, the true burden of pertussis, including age-stratified incidence and risk factors of severe sequelae, are under-recognised. We aim to estimate the health burden of laboratory-confirmed pertussis by age groups, considering the setting of illness onset (ie, in community, outpatient and inpatient), in a Chinese population (~2.23 million in total) at two sites.<h4>Methods and analysis</h4>This paper describes the study design of a 1-year, prospective, age-stratified and population-based case-control study, including site selection, study population, case registry, ascertainment and enrolment, control recruitBMJ openBurden of whooping cough in China (PertussisChina): study protocol of a prospective, population-based case-control study.PMC89152822018ZX09737-007L19206081973106Xu LZhou QZhu YGuo YHe HYu JChen CXu JShao ZChen ZZhang YZhang XGao YTang XfalseBurden of whooping cough in China (PertussisChina): study protocol of a prospective, population-based case-control study.<h4>Introduction</h4>Pertussis is one of the top 10 diseases of children under 10 years of age, and the few vaccine-preventable diseases who is on a rise in China in recent years; however, the true burden of pertussis, including age-stratified incidence and risk factors of severe sequelae, are under-recognised. We aim to estimate the health burden of laboratory-confirmed pertussis by age groups, considering the setting of illness onset (ie, in community, outpatient and inpatient), in a Chinese population (~2.23 million in total) at two sites.<h4>Methods and analysis</h4>This paper describes the study design of a 1-year, prospective, age-stratified and population-based case-control study, including site selection, study population, case registry, ascertainment and enrolment, control recruit2022-01-01T00:00:00Z2022 Mar2026-05-30T23:16:05.965Z2024-11-08T15:28:14.523ZS-EPMC89152823527304610.1136/bmjopen-2021-053316