{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Li X"],"funding":["National Natural Science Foundation of China"],"pubmed_abstract":["Incomplete recovery from acute kidney injury induced by folic acid is a major risk factor for progression to chronic kidney disease. Mitochondrial dysfunction has been considered a crucial contributor to maladaptive repair in acute kidney injury. Treatment with FG-4592, an inhibitor of hypoxia inducible factor prolyl-hydroxylase, is emerging as a new approach to attenuate renal damage; however, the underlying mechanism has not been fully elucidated. The current research demonstrated the protective effect of FG-4592 against renal dysfunction and histopathological damage on the 7th day after FA administration. FG-4592 accelerated tubular repair by promoting tubular cell regeneration, as indicated by increased proliferation of cell nuclear antigen-positive tubular cells, and facilitated struc"],"journal":["Frontiers in pharmacology"],"pagination":["788977"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8915431"],"repository":["biostudies-literature"],"pubmed_title":["Roxadustat (FG-4592) Facilitates Recovery From Renal Damage by Ameliorating Mitochondrial Dysfunction Induced by Folic Acid."],"pmcid":["PMC8915431"],"pubmed_authors":["Li X","Zou Y","Fu YY","Zhai XY","Zhang J","Jiang B"],"additional_accession":[]},"is_claimable":false,"name":"Roxadustat (FG-4592) Facilitates Recovery From Renal Damage by Ameliorating Mitochondrial Dysfunction Induced by Folic Acid.","description":"Incomplete recovery from acute kidney injury induced by folic acid is a major risk factor for progression to chronic kidney disease. Mitochondrial dysfunction has been considered a crucial contributor to maladaptive repair in acute kidney injury. Treatment with FG-4592, an inhibitor of hypoxia inducible factor prolyl-hydroxylase, is emerging as a new approach to attenuate renal damage; however, the underlying mechanism has not been fully elucidated. The current research demonstrated the protective effect of FG-4592 against renal dysfunction and histopathological damage on the 7th day after FA administration. FG-4592 accelerated tubular repair by promoting tubular cell regeneration, as indicated by increased proliferation of cell nuclear antigen-positive tubular cells, and facilitated struc","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-08-23T03:08:57.482Z","creation":"2025-04-04T14:50:37.694Z"},"accession":"S-EPMC8915431","cross_references":{"pubmed":["35280255"],"doi":["10.3389/fphar.2021.788977"]}}