{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mu R"],"funding":["Korea National Institute of Health","NCI NIH HHS","V Foundation for Cancer Research"],"pagination":["1302-1312"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8916708"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["149(6)"],"pubmed_abstract":["The mitotic phase is a vital step in cell division and may be involved in cancer progression, but it remains unclear whether genetic variants in mitotic phase-related pathways genes impact the survival of these patients. Here, we investigated associations between 31 032 single nucleotide polymorphisms (SNPs) in 368 mitotic phase-related pathway genes and overall survival (OS) of patients with nonsmall cell lung cancer (NSCLC). We assessed the associations in a discovery data set of 1185 NSCLC patients from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial and validated the findings in another data set of 984 patients from the Harvard Lung Cancer Susceptibility Study. As a result, we identified three independent SNPs (ie, CHEK1 rs76744140 T>C, PRIM2 rs6939623 G>T and "],"journal":["International journal of cancer"],"pubmed_title":["Genetic variants of CHEK1, PRIM2 and CDK6 in the mitotic phase-related pathway are associated with nonsmall cell lung cancer survival."],"pmcid":["PMC8916708"],"funding_grant_id":["R01 CA092824","D2017‐19","P50 CA090578","CA092824","P20 CA090578","CA074386","CA090578","U01 CA209414","P30 CA014236","CA209414","R01 CA074386"],"pubmed_authors":["Liu H","Wei Q","Patz EF","Su L","Christiani DC","Luo S","Glass C","Mu R","Du M","Jin L"],"additional_accession":[]},"is_claimable":false,"name":"Genetic variants of CHEK1, PRIM2 and CDK6 in the mitotic phase-related pathway are associated with nonsmall cell lung cancer survival.","description":"The mitotic phase is a vital step in cell division and may be involved in cancer progression, but it remains unclear whether genetic variants in mitotic phase-related pathways genes impact the survival of these patients. Here, we investigated associations between 31 032 single nucleotide polymorphisms (SNPs) in 368 mitotic phase-related pathway genes and overall survival (OS) of patients with nonsmall cell lung cancer (NSCLC). We assessed the associations in a discovery data set of 1185 NSCLC patients from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial and validated the findings in another data set of 984 patients from the Harvard Lung Cancer Susceptibility Study. As a result, we identified three independent SNPs (ie, CHEK1 rs76744140 T>C, PRIM2 rs6939623 G>T and ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2026-05-31T11:53:23.204Z","creation":"2025-04-05T22:20:20.518Z"},"accession":"S-EPMC8916708","cross_references":{"pubmed":["34058013"],"doi":["10.1002/ijc.33702"]}}