biostudies-literatureHazan GNHLBI NIH HHSChildren's Discovery InstituteHHS | NIH | National Heart, Lung, and Blood Institute1467-1482https://www.ebi.ac.uk/biostudies/studies/S-EPMC8917060biostudies-literatureUnknown208(6)Asthma is a chronic disease of childhood, but for unknown reasons, disease activity sometimes subsides as children mature. In this study, we present clinical and animal model evidence suggesting that the age dependency of childhood asthma stems from an evolving host response to respiratory viral infection. Using clinical data, we show that societal suppression of respiratory virus transmission during coronavirus disease 2019 lockdown disrupted the traditional age gradient in pediatric asthma exacerbations, connecting the phenomenon of asthma remission to virus exposure. In mice, we show that asthmatic lung pathology triggered by Sendai virus (SeV) or influenza A virus is highly age-sensitive: robust in juvenile mice (4-6 wk old) but attenuated in mature mice (>3 mo old). Interestingly, allJournal of immunology (Baltimore, Md. : 1950)Age-Dependent Reduction in Asthmatic Pathology through Reprogramming of Postviral Inflammatory Responses.PMC8917060R01 HL135846R35 HL145242R01 HL152245R01 HL152968PD-II-2016-529Wu KWhite MKau ALEiden EKelley DKeeler SPByers DEubanks AAlexander-Brett JAtkinson JKoenitzer JRHaspel JSteinberg DHernandez-Leyva AAgapov EAnderson NZhang YFox CHoltzman MJHazan GGierasch CRosen ALfalseAge-Dependent Reduction in Asthmatic Pathology through Reprogramming of Postviral Inflammatory Responses.Asthma is a chronic disease of childhood, but for unknown reasons, disease activity sometimes subsides as children mature. In this study, we present clinical and animal model evidence suggesting that the age dependency of childhood asthma stems from an evolving host response to respiratory viral infection. Using clinical data, we show that societal suppression of respiratory virus transmission during coronavirus disease 2019 lockdown disrupted the traditional age gradient in pediatric asthma exacerbations, connecting the phenomenon of asthma remission to virus exposure. In mice, we show that asthmatic lung pathology triggered by Sendai virus (SeV) or influenza A virus is highly age-sensitive: robust in juvenile mice (4-6 wk old) but attenuated in mature mice (>3 mo old). Interestingly, all2022-01-01T00:00:00Z2022 Mar2026-05-09T22:14:05.388Z2024-11-19T16:59:49.272ZS-EPMC89170603517303710.4049/jimmunol.2101094