{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Belcheva AB"],"funding":["Medical University of Plovdiv: medicinski universitet-plovdiv"],"pagination":["208"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8917669"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Introduction</h4>White spot lesions associated with orthodontic treatment are a common problem. Recent studies reported increased resistance to acid demineralization of enamel after sub-ablative CO<sub>2</sub>-laser irradiation in a combination with fluoride application. The aim of the study is to assess the efficacy of CO<sub>2</sub>-laser in combination with a fluoride varnish in the prevention, severity, and extent of white spot lesions during orthodontic treatment with fixed appliances.<h4>Methods and analysis</h4>This is a protocol for a randomized, split-mouth controlled, clinical trial. The participants will be children aged 12-18 years at high caries risk, requiring fixed orthodontic treatment. The vestibular surfaces of maxillary anterior teeth of eligible patients will be exposed to CO<sub>2</sub>-laser irradiation in combination with fluoride therapy and fluoride therapy alone followed by bonding of orthodontic brackets. The patients will be recalled 6 and 12 months post-irradiation. Outcome measures will be visual examination with International Caries Detection and Assessment System criteria and SoproLife fluorescence. Data will be analyzed by Student's t test for paired samples and proportional odds logistic regression model, p<0.05.<h4>Ethics and dissemination</h4>The study protocol has been approved by the Committee for Scientific Research Ethics, Medical University-Plovdiv, Bulgaria (Reference number P-605/27.03.2020, Protocol of approval No. 2/01.04.2021) and registered on a publicly accessible database. This research received institutional funding from the Medical University-Plovdiv, Bulgaria. The results will be presented through peer-reviewed publications and conference presentations.<h4>Trial registration</h4>ClinicalTrials.gov NCT04903275 . Registered on June 2021."],"journal":["Trials"],"pubmed_title":["Caries inhibition with CO<sub>2</sub>-laser during orthodontic treatment: a study protocol for a randomized split-mouth controlled clinical trial."],"pmcid":["PMC8917669"],"funding_grant_id":["n/a"],"pubmed_authors":["Belcheva AB","Shindova MP"],"additional_accession":[]},"is_claimable":false,"name":"Caries inhibition with CO<sub>2</sub>-laser during orthodontic treatment: a study protocol for a randomized split-mouth controlled clinical trial.","description":"<h4>Introduction</h4>White spot lesions associated with orthodontic treatment are a common problem. Recent studies reported increased resistance to acid demineralization of enamel after sub-ablative CO<sub>2</sub>-laser irradiation in a combination with fluoride application. The aim of the study is to assess the efficacy of CO<sub>2</sub>-laser in combination with a fluoride varnish in the prevention, severity, and extent of white spot lesions during orthodontic treatment with fixed appliances.<h4>Methods and analysis</h4>This is a protocol for a randomized, split-mouth controlled, clinical trial. The participants will be children aged 12-18 years at high caries risk, requiring fixed orthodontic treatment. The vestibular surfaces of maxillary anterior teeth of eligible patients will be exposed to CO<sub>2</sub>-laser irradiation in combination with fluoride therapy and fluoride therapy alone followed by bonding of orthodontic brackets. The patients will be recalled 6 and 12 months post-irradiation. Outcome measures will be visual examination with International Caries Detection and Assessment System criteria and SoproLife fluorescence. Data will be analyzed by Student's t test for paired samples and proportional odds logistic regression model, p<0.05.<h4>Ethics and dissemination</h4>The study protocol has been approved by the Committee for Scientific Research Ethics, Medical University-Plovdiv, Bulgaria (Reference number P-605/27.03.2020, Protocol of approval No. 2/01.04.2021) and registered on a publicly accessible database. This research received institutional funding from the Medical University-Plovdiv, Bulgaria. The results will be presented through peer-reviewed publications and conference presentations.<h4>Trial registration</h4>ClinicalTrials.gov NCT04903275 . Registered on June 2021.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-05-30T16:49:51.185Z","creation":"2025-02-19T05:04:51.356Z"},"accession":"S-EPMC8917669","cross_references":{"pubmed":["35279220"],"doi":["10.1186/s13063-022-06117-y"]}}