{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Polites VC"],"funding":["Division of Chemistry","Bristol-Myers Squibb","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["4828-4833"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8917872"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(12)"],"pubmed_abstract":["The use of bicyclo[1.1.1]pentanes (BCPs) as <i>para</i>-disubstituted aryl bioisosteres has gained considerable momentum in drug development programs. Carbon-carbon bond formation via transition-metal-mediated cross-coupling represents an attractive strategy to generate BCP-aryl compounds for late-stage functionalization, but these typically require reactive organometallics to prepare BCP nucleophiles on demand from [1.1.1]propellane. In this study, the synthesis and Ni-catalyzed functionalization of BCP redox-active esters with (hetero)aryl bromides via the action of a photoactive electron donor-acceptor complex are reported."],"journal":["Organic letters"],"pubmed_title":["Nickel-Catalyzed Decarboxylative Cross-Coupling of Bicyclo[1.1.1]pentyl Radicals Enabled by Electron Donor-Acceptor Complex Photoactivation."],"pmcid":["PMC8917872"],"funding_grant_id":["R01 GM087605","NSF CHE-1827457","R01GM087605-06S1","R01GM118510-03S1","R01 GM118510","R35 GM 131680","R35 GM131680"],"pubmed_authors":["Badir SO","Polites VC","Molander GA","Jolit A","Keess S"],"additional_accession":[]},"is_claimable":false,"name":"Nickel-Catalyzed Decarboxylative Cross-Coupling of Bicyclo[1.1.1]pentyl Radicals Enabled by Electron Donor-Acceptor Complex Photoactivation.","description":"The use of bicyclo[1.1.1]pentanes (BCPs) as <i>para</i>-disubstituted aryl bioisosteres has gained considerable momentum in drug development programs. Carbon-carbon bond formation via transition-metal-mediated cross-coupling represents an attractive strategy to generate BCP-aryl compounds for late-stage functionalization, but these typically require reactive organometallics to prepare BCP nucleophiles on demand from [1.1.1]propellane. In this study, the synthesis and Ni-catalyzed functionalization of BCP redox-active esters with (hetero)aryl bromides via the action of a photoactive electron donor-acceptor complex are reported.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-19T17:38:24.441Z","creation":"2025-04-19T17:38:24.441Z"},"accession":"S-EPMC8917872","cross_references":{"pubmed":["34100624"],"doi":["10.1021/acs.orglett.1c01558"]}}