biostudies-literatureUnknown61(4)Onal H<h4>Aim</h4>To determine whether convalescent angiotensin (1-7) peptide replacement therapy with plasma (peptide plasma) transfusion can be beneficial in the treatment of critically ill patients with severe coronavirus 2 (SARS-CoV-2) infection.<h4>Study design</h4>Case series of 9 critically ill patients with laboratory-confirmed COVID-19 who met the following criteria: severe pneumonia with rapid progression and continuously high viral load despite antiviral treatment. Peptide plasma: Plasma with angiotensin (1-7) content 8-10 times higher than healthy plasma donors was obtained from suitable donors. Peptide plasma transfusion was applied to 9 patients whose clinical status and/or laboratory profile deteriorated and who needed intensive care for 2 days.<h4>Results</h4>In our COVID-19 caseTransfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis103418https://www.ebi.ac.uk/biostudies/studies/S-EPMC8917875biostudies-literatureAngiotensin (1-7) peptide replacement therapy with plasma transfusion in COVID-19.PMC8917875Kalkan AArslan BOnal HSemerci SYErgun NUTopuz SKocatas AUgurel OMTopuzogullari MSuner NYoldemir SAfalseAngiotensin (1-7) peptide replacement therapy with plasma transfusion in COVID-19.<h4>Aim</h4>To determine whether convalescent angiotensin (1-7) peptide replacement therapy with plasma (peptide plasma) transfusion can be beneficial in the treatment of critically ill patients with severe coronavirus 2 (SARS-CoV-2) infection.<h4>Study design</h4>Case series of 9 critically ill patients with laboratory-confirmed COVID-19 who met the following criteria: severe pneumonia with rapid progression and continuously high viral load despite antiviral treatment. Peptide plasma: Plasma with angiotensin (1-7) content 8-10 times higher than healthy plasma donors was obtained from suitable donors. Peptide plasma transfusion was applied to 9 patients whose clinical status and/or laboratory profile deteriorated and who needed intensive care for 2 days.<h4>Results</h4>In our COVID-19 case2022-01-01T00:00:00Z2022 Aug2025-04-19T22:56:52.453Z2024-11-19T21:53:54.647ZS-EPMC89178753530592310.1016/j.transci.2022.103418