{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["38(23)"],"submitter":["Max JE"],"pubmed_abstract":["The objective was to clarify occurrence, phenomenology, and risk factors for novel psychiatric disorder (NPD) in the first 3 months after mild traumatic brain injury (mTBI) and orthopedic injury (OI). Children aged 8-15 years with mTBI (<i>n</i> = 220) and with OI but no TBI (<i>n</i> = 110) from consecutive admissions to an emergency department were followed prospectively at baseline and 3 months post-injury with semi-structured psychiatric interviews to document the number of NPDs that developed in each participant. Pre-injury child variables (adaptive, cognitive, and academic function, and psychiatric disorder), pre-injury family variables (socioeconomic status, family psychiatric history, and family function), and injury severity were assessed and analyzed as potential confounders and predictors of NPD. NPD occurred at a significantly higher frequency in children with mTBI versus OI in analyses unadjusted (mean ratio [MR] 3.647, 95% confidence interval [CI<sub>95</sub>] (1.264, 15.405), <i>p</i> = 0.014) and adjusted (MR = 3.724, CI<sub>95</sub> (1.264, 15.945), <i>p</i> = 0.015) for potential confounders. In multi-predictor analyses, the factors besides mTBI that were significantly associated with higher NPD frequency after adjustment for each other were pre-injury lifetime psychiatric disorder [MR = 2.284, CI<sub>95</sub> (1.026, 5.305), <i>p</i> = 0.043]; high versus low family psychiatric history [MR = 2.748, CI<sub>95</sub> (1.201, 6.839), <i>p</i> = 0.016], and worse socio-economic status [MR = 0.618 per additional unit, CI<sub>95</sub> (0.383, 0.973), <i>p</i> = 0.037]. These findings demonstrate that mild injury to the brain compared with an OI had a significantly greater deleterious effect on psychiatric outcome in the first 3 months post-injury. This effect was present even after accounting for specific child and family variables, which were themselves independently related to the adverse psychiatric outcome."],"journal":["Journal of neurotrauma"],"pagination":["3341-3351"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8917890"],"repository":["biostudies-literature"],"pubmed_title":["Three-Month Psychiatric Outcome of Pediatric Mild Traumatic Brain Injury: A Controlled Study."],"pmcid":["PMC8917890"],"pubmed_authors":["De La Garza BG","Max JE","Calahorra A","Vaida F","Bigler ED","Patterson JE","Edwards TM","Wilde EA","Judd N"],"additional_accession":[]},"is_claimable":false,"name":"Three-Month Psychiatric Outcome of Pediatric Mild Traumatic Brain Injury: A Controlled Study.","description":"The objective was to clarify occurrence, phenomenology, and risk factors for novel psychiatric disorder (NPD) in the first 3 months after mild traumatic brain injury (mTBI) and orthopedic injury (OI). Children aged 8-15 years with mTBI (<i>n</i> = 220) and with OI but no TBI (<i>n</i> = 110) from consecutive admissions to an emergency department were followed prospectively at baseline and 3 months post-injury with semi-structured psychiatric interviews to document the number of NPDs that developed in each participant. Pre-injury child variables (adaptive, cognitive, and academic function, and psychiatric disorder), pre-injury family variables (socioeconomic status, family psychiatric history, and family function), and injury severity were assessed and analyzed as potential confounders and predictors of NPD. NPD occurred at a significantly higher frequency in children with mTBI versus OI in analyses unadjusted (mean ratio [MR] 3.647, 95% confidence interval [CI<sub>95</sub>] (1.264, 15.405), <i>p</i> = 0.014) and adjusted (MR = 3.724, CI<sub>95</sub> (1.264, 15.945), <i>p</i> = 0.015) for potential confounders. In multi-predictor analyses, the factors besides mTBI that were significantly associated with higher NPD frequency after adjustment for each other were pre-injury lifetime psychiatric disorder [MR = 2.284, CI<sub>95</sub> (1.026, 5.305), <i>p</i> = 0.043]; high versus low family psychiatric history [MR = 2.748, CI<sub>95</sub> (1.201, 6.839), <i>p</i> = 0.016], and worse socio-economic status [MR = 0.618 per additional unit, CI<sub>95</sub> (0.383, 0.973), <i>p</i> = 0.037]. These findings demonstrate that mild injury to the brain compared with an OI had a significantly greater deleterious effect on psychiatric outcome in the first 3 months post-injury. This effect was present even after accounting for specific child and family variables, which were themselves independently related to the adverse psychiatric outcome.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-04T19:38:03.073Z","creation":"2025-04-04T19:38:03.073Z"},"accession":"S-EPMC8917890","cross_references":{"pubmed":["34714155"],"doi":["10.1089/neu.2021.0324"]}}