{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vaccarino V"],"funding":["Office of Research and Development","NCRR NIH HHS","NIA NIH HHS","NHLBI NIH HHS","NIH","U.S. Department of Veterans Affairs"],"pagination":["615-625"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8918004"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["91(7)"],"pubmed_abstract":["Background
The link between posttraumatic stress disorder (PTSD) and ischemic heart disease remains elusive owing to a shortage of longitudinal studies with a clinical diagnosis of PTSD and objective measures of cardiac compromise.Methods
We performed positron emission tomography in 275 twins who participated in two examinations approximately 12 years apart. At both visits, we obtained a clinical diagnosis of PTSD, which was classified as long-standing (both visit 1 and visit 2), late onset (only visit 2), and no PTSD (no PTSD at both visits). With positron emission tomography, we assessed myocardial flow reserve (MFR), which, in absence of significant coronary stenoses, indexes coronary microvascular function. We compared positron emission tomography data at visit 2 across"],"journal":["Biological psychiatry"],"pubmed_title":["Posttraumatic Stress Disorder, Myocardial Perfusion, and Myocardial Blood Flow: A Longitudinal Twin Study."],"pmcid":["PMC8918004"],"funding_grant_id":["K24 HL077506","T32 HL130025","M01 RR000039","R01 HL68630","2K24 HL077506","R01 HL125246","K23 HL127251","R01 HL136205","R01 HL068630","R01 AG026255"],"pubmed_authors":["Young A","Haffar A","Hammadah M","Nye J","Ma X","Bremner JD","Quyyumi AA","Alkhalaf M","Raggi P","Murrah N","Shah AJ","Levantsevych OM","Driggers E","Moncayo V","Smith NL","Vaccarino V","Ko YA","O'Neal W","Garcia EV","Piccinelli M","Goldberg J","Shallenberger L","Lima BB"],"additional_accession":[]},"is_claimable":false,"name":"Posttraumatic Stress Disorder, Myocardial Perfusion, and Myocardial Blood Flow: A Longitudinal Twin Study.","description":"Background
The link between posttraumatic stress disorder (PTSD) and ischemic heart disease remains elusive owing to a shortage of longitudinal studies with a clinical diagnosis of PTSD and objective measures of cardiac compromise.Methods
We performed positron emission tomography in 275 twins who participated in two examinations approximately 12 years apart. At both visits, we obtained a clinical diagnosis of PTSD, which was classified as long-standing (both visit 1 and visit 2), late onset (only visit 2), and no PTSD (no PTSD at both visits). With positron emission tomography, we assessed myocardial flow reserve (MFR), which, in absence of significant coronary stenoses, indexes coronary microvascular function. We compared positron emission tomography data at visit 2 across","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-22T11:54:14.106Z","creation":"2025-04-22T11:54:14.106Z"},"accession":"S-EPMC8918004","cross_references":{"pubmed":["34865854"],"doi":["10.1016/j.biopsych.2021.09.016"]}}