{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mondatore D"],"funding":["University of Milan","Fondazione Regionale della Ricerca Biomedica"],"pagination":["ofac046"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8918388"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(4)"],"pubmed_abstract":["<h4>Background</h4>People with HIV are at increased risk of human papillomavirus (HPV) disease progression, given the persistence of immune activation and residual inflammation despite effective combination antiretroviral therapy (cART). Whether a low CD4:CD8 T-cell ratio, known to mirror peripheral immune dysfunction, is associated with squamous intraepithelial lesions (SILs) is unknown.<h4>Methods</h4>This was a retrospective cohort study on cART-treated HIV-positive subjects undergoing screening for HPV-related dysplasia (anal/cervical cytology and HPV genotyping). SIL was defined as the presence of either atypical squamous cells of undetermined significance (ASCUS), low-grade SILs, or high-grade SILs. Demographic and viro-immunological parameters (T-cell count, CD4:CD8 T-cell ratio, CD"],"journal":["Open forum infectious diseases"],"pubmed_title":["Persistence of High Percentage of Peripheral Activated CD8+ T Cells Predict Cytologic HPV-Related Dysplasia in cART-Treated, HIV-Positive Subjects."],"pmcid":["PMC8918388"],"funding_grant_id":["073"],"pubmed_authors":["Augello M","Pisani Ceretti A","Marchetti GC","Mondatore D","Tincati C","d'Arminio Monforte A","Giovenzana M","Bono V","Opocher E","Bai F"],"additional_accession":[]},"is_claimable":false,"name":"Persistence of High Percentage of Peripheral Activated CD8+ T Cells Predict Cytologic HPV-Related Dysplasia in cART-Treated, HIV-Positive Subjects.","description":"<h4>Background</h4>People with HIV are at increased risk of human papillomavirus (HPV) disease progression, given the persistence of immune activation and residual inflammation despite effective combination antiretroviral therapy (cART). Whether a low CD4:CD8 T-cell ratio, known to mirror peripheral immune dysfunction, is associated with squamous intraepithelial lesions (SILs) is unknown.<h4>Methods</h4>This was a retrospective cohort study on cART-treated HIV-positive subjects undergoing screening for HPV-related dysplasia (anal/cervical cytology and HPV genotyping). SIL was defined as the presence of either atypical squamous cells of undetermined significance (ASCUS), low-grade SILs, or high-grade SILs. Demographic and viro-immunological parameters (T-cell count, CD4:CD8 T-cell ratio, CD","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-19T12:55:14.642Z","creation":"2025-04-19T12:55:14.642Z"},"accession":"S-EPMC8918388","cross_references":{"pubmed":["35291446"],"doi":["10.1093/ofid/ofac046"]}}