{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Chen Y"],"pubmed_abstract":["<h4>Background</h4>Perturbation of tryptophan (TRP) metabolism contributes to the immune escape of cancer; however, the explored TRP metabolites are limited, and their efficacy in clarifying the susceptibility and progression of esophageal cancer (EC) remains ambiguous. Our study sought to evaluate the effects of the TRP metabolic profile on the clinical outcomes of EC using a Chinese population cohort; and to develop a risk prediction model targeting TRP metabolism.<h4>Method</h4>A total of 456 healthy individuals as control subjects and 393 patients with EC who were followed up for one year as case subjects were enrolled. Quantification of the plasma concentrations of TRP and its metabolites was performed using HPLC-MS/MS. The logistic regression model was applied to evaluate the effects"],"journal":["Frontiers in oncology"],"pagination":["800291"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8918692"],"repository":["biostudies-literature"],"pubmed_title":["Tryptophan Metabolites as Biomarkers for Esophageal Cancer Susceptibility, Metastasis, and Prognosis."],"pmcid":["PMC8918692"],"pubmed_authors":["Zhao C","Lin C","Chen J","Zhong S","Yang P","Xu C","Chen Y","Guo D","Chen S","Zhang S","Zhang Q"],"additional_accession":[]},"is_claimable":false,"name":"Tryptophan Metabolites as Biomarkers for Esophageal Cancer Susceptibility, Metastasis, and Prognosis.","description":"<h4>Background</h4>Perturbation of tryptophan (TRP) metabolism contributes to the immune escape of cancer; however, the explored TRP metabolites are limited, and their efficacy in clarifying the susceptibility and progression of esophageal cancer (EC) remains ambiguous. Our study sought to evaluate the effects of the TRP metabolic profile on the clinical outcomes of EC using a Chinese population cohort; and to develop a risk prediction model targeting TRP metabolism.<h4>Method</h4>A total of 456 healthy individuals as control subjects and 393 patients with EC who were followed up for one year as case subjects were enrolled. Quantification of the plasma concentrations of TRP and its metabolites was performed using HPLC-MS/MS. The logistic regression model was applied to evaluate the effects","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T20:38:12.668Z","creation":"2025-04-04T20:38:12.668Z"},"accession":"S-EPMC8918692","cross_references":{"pubmed":["35296014"],"doi":["10.3389/fonc.2022.800291"]}}