{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Li M"],"pubmed_abstract":["Psoriasis is a chronic skin disorder associated with multiple sequelae, such as psoriatic arthritis and cardiovascular diseases. Increasing evidence has shown that γδ T cells, as sources of IL-17A, play critical roles in psoriatic inflammations. However, there still lack effective ways to manipulate these pathogenic γδ T cells, which are less well studied than αβ T cells. The present study aims to characterize the phenotype of γδ T cells and evaluate the impact of D-mannose (a C-2 epimer of glucose) on γδ T cell-mediated psoriasis. We found that skin-draining LN γδ T cells underwent robust proliferation and acquired an IL-17-producing phenotype during psoriasis. The transcriptomic profiles of these psoriatic γδ T cells had elevated glycolytic signatures. Importantly, D-mannose treatment su"],"journal":["Frontiers in immunology"],"pagination":["840755"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8918796"],"repository":["biostudies-literature"],"pubmed_title":["D-Mannose Suppresses γδ T Cells and Alleviates Murine Psoriasis."],"pmcid":["PMC8918796"],"pubmed_authors":["Pan Y","Zhang D","Yang L","Mei X","Du X","Tian D","Cheng H","Li M"],"additional_accession":[]},"is_claimable":false,"name":"D-Mannose Suppresses γδ T Cells and Alleviates Murine Psoriasis.","description":"Psoriasis is a chronic skin disorder associated with multiple sequelae, such as psoriatic arthritis and cardiovascular diseases. Increasing evidence has shown that γδ T cells, as sources of IL-17A, play critical roles in psoriatic inflammations. However, there still lack effective ways to manipulate these pathogenic γδ T cells, which are less well studied than αβ T cells. The present study aims to characterize the phenotype of γδ T cells and evaluate the impact of D-mannose (a C-2 epimer of glucose) on γδ T cell-mediated psoriasis. We found that skin-draining LN γδ T cells underwent robust proliferation and acquired an IL-17-producing phenotype during psoriasis. The transcriptomic profiles of these psoriatic γδ T cells had elevated glycolytic signatures. Importantly, D-mannose treatment su","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-30T20:47:56.643Z","creation":"2025-05-29T22:21:16.496Z"},"accession":"S-EPMC8918796","cross_references":{"pubmed":["35296088"],"doi":["10.3389/fimmu.2022.840755"]}}