{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Delorey TM"],"funding":["NIDDK NIH HHS","Howard Hughes Medical Institute","NIMH NIH HHS","NIAAA NIH HHS","NHGRI NIH HHS","NCI NIH HHS","Wellcome Trust","NIGMS NIH HHS"],"pagination":["107-113"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8919505"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["595(7865)"],"pubmed_abstract":["COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome and multiple organ failure<sup>1-4</sup>, but little is known about its pathophysiology. Here we generated single-cell atlases of 24 lung, 16 kidney, 16 liver and 19 heart autopsy tissue samples and spatial atlases of 14 lung samples from donors who died of COVID-19. Integrated computational analysis uncovered substantial remodelling in the lung epithelial, immune and stromal compartments, with evidence of multiple paths of failed tissue regeneration, including defective alveolar type 2 differentiation and expansion of fibroblasts and putative TP63<sup>+</sup> intrapulmonary basal-like progenitor cells. Viral RNAs were enriched in mononuclear phagocytic and endothelial lung cells, which induced speci"],"journal":["Nature"],"pubmed_title":["COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets."],"pmcid":["PMC8919505"],"funding_grant_id":["DP2 CA247831","T32 GM007753","R37 MH107649","P30 CA013696","R01 AA020744","R01 MH107649","U01 AA026933","R01 MH101244","P30 DK046200","K08 CA222663","R37 CA258829","U01 HG009379","U54 CA225088"],"pubmed_authors":["Farhi SL","Muus C","Sud M","Zhang S","Tsai LT","Juric D","Grzyb J","Ingber DE","Jiang ZG","Gazal S","Slyper M","Hibshoosh H","Miller EM","Rozenblatt-Rosen O","Niezen S","Vellarikkal SK","Heimberg G","Ellinor PT","Novak R","Rueckert EH","Price AL","Tran VM","Raju SS","Hacohen N","Biermann J","Waghray A","Brook OR","Harvey T","Katsyv I","Plaisted J","Cosimi L","Abbondanza D","Ross M","Dey KK","Vlachos IS","Bloom-Ackermann Z","Babadi M","Porter CBM","Li B","Barkas N","Ziegler CGK","Normand R","Reeves J","Segerstolpe A","Gould J","Ganna A","Pfiffner-Borges J","Tickle TL","Pita-Juarez YH","Shalek AK","Hether T","Atri DS","Naderi P","Jane-Valbuena J","Sabeti PC","Normandin E","Ashenberg O","Warren S","Tata PR","Subramanian A","Sturm A","Siddle KJ","Izar B","Zollinger DR","Villani AC","Dorceus P","Engreitz JM","Wang Y","Leney-Greene M","Hecht J","Chen J","Essene A","Niemi M","Siciliano M","Sen P","Melms JC","Beechem J","Yang Y","Delorey TM","Gupta RM","Rajagopal J","Szabo G","Pinto CJ","Divakar P","Popov YV","McCabe C","Riedel S","Jagadeesh KA","Hide W","McLoughlin DE","Hung D","Rogers R","Fleming SJ","Phillips D","Pe'er C","Amir-Zilberstein L","Fitzgerald DM","Fropf R","Rudy M","Todres E","Solomon IH","Gomez J","Padera R","Pant D","Regev A","Montoro DT","Ma H","Stone JR","Pan L"],"additional_accession":[]},"is_claimable":false,"name":"COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.","description":"COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome and multiple organ failure<sup>1-4</sup>, but little is known about its pathophysiology. Here we generated single-cell atlases of 24 lung, 16 kidney, 16 liver and 19 heart autopsy tissue samples and spatial atlases of 14 lung samples from donors who died of COVID-19. Integrated computational analysis uncovered substantial remodelling in the lung epithelial, immune and stromal compartments, with evidence of multiple paths of failed tissue regeneration, including defective alveolar type 2 differentiation and expansion of fibroblasts and putative TP63<sup>+</sup> intrapulmonary basal-like progenitor cells. Viral RNAs were enriched in mononuclear phagocytic and endothelial lung cells, which induced speci","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2025-04-29T11:01:38.104Z","creation":"2025-04-06T19:47:24.52Z"},"accession":"S-EPMC8919505","cross_references":{"pubmed":["33915569"],"doi":["10.1038/s41586-021-03570-8"]}}