{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(1)"],"submitter":["Heyn J"],"funding":["Johann Wolfgang Goethe-Universität, Frankfurt am Main","sandoz biopharmaceuticals/hexal ag"],"pubmed_abstract":["<h4>Background</h4>Safety, tolerability and efficacy of granulocyte colony-stimulating factor (G-CSF) for mobilization of hematopoietic stem and progenitor cells (HSPCs) from healthy donors have been conclusively demonstrated. This explicitly includes, albeit for smaller cohorts and shorter observation periods, biosimilar G-CSFs. HSPC donation is non-remunerated, its sole reward being \"warm glow\", hence harm to donors must be avoided with maximal certitude. To ascertain, therefore, long-term physical and mental health effects of HSPC donation, a cohort of G-CSF mobilized donors was followed longitudinally.<h4>Methods</h4>We enrolled 245 healthy volunteers in this bi-centric long-term surveillance study. 244 healthy volunteers began mobilization with twice-daily Sandoz biosimilar filgrastim"],"journal":["Journal of translational medicine"],"pagination":["121"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8919626"],"repository":["biostudies-literature"],"pubmed_title":["Superior physical and mental health of healthy volunteers before and five years after mobilized stem cell donation."],"pmcid":["PMC8919626"],"pubmed_authors":["Bonig H","Brauninger S","Kolpakova A","Seifried E","Reinhardt P","Nakov R","Mathieson N","Dimova-Dobreva M","Seidl C","Heyn J","Koptelova N","Tsamadou C","Schrezenmeier H"],"additional_accession":[]},"is_claimable":false,"name":"Superior physical and mental health of healthy volunteers before and five years after mobilized stem cell donation.","description":"<h4>Background</h4>Safety, tolerability and efficacy of granulocyte colony-stimulating factor (G-CSF) for mobilization of hematopoietic stem and progenitor cells (HSPCs) from healthy donors have been conclusively demonstrated. This explicitly includes, albeit for smaller cohorts and shorter observation periods, biosimilar G-CSFs. HSPC donation is non-remunerated, its sole reward being \"warm glow\", hence harm to donors must be avoided with maximal certitude. To ascertain, therefore, long-term physical and mental health effects of HSPC donation, a cohort of G-CSF mobilized donors was followed longitudinally.<h4>Methods</h4>We enrolled 245 healthy volunteers in this bi-centric long-term surveillance study. 244 healthy volunteers began mobilization with twice-daily Sandoz biosimilar filgrastim","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-06-01T02:37:17.797Z","creation":"2024-10-16T15:09:05.276Z"},"accession":"S-EPMC8919626","cross_references":{"pubmed":["35287672"],"doi":["10.1186/s12967-022-03322-w"]}}