biostudies-literatureUnknown20(1)Heyn JJohann Wolfgang Goethe-Universität, Frankfurt am Mainsandoz biopharmaceuticals/hexal ag<h4>Background</h4>Safety, tolerability and efficacy of granulocyte colony-stimulating factor (G-CSF) for mobilization of hematopoietic stem and progenitor cells (HSPCs) from healthy donors have been conclusively demonstrated. This explicitly includes, albeit for smaller cohorts and shorter observation periods, biosimilar G-CSFs. HSPC donation is non-remunerated, its sole reward being "warm glow", hence harm to donors must be avoided with maximal certitude. To ascertain, therefore, long-term physical and mental health effects of HSPC donation, a cohort of G-CSF mobilized donors was followed longitudinally.<h4>Methods</h4>We enrolled 245 healthy volunteers in this bi-centric long-term surveillance study. 244 healthy volunteers began mobilization with twice-daily Sandoz biosimilar filgrastimJournal of translational medicine121https://www.ebi.ac.uk/biostudies/studies/S-EPMC8919626biostudies-literatureSuperior physical and mental health of healthy volunteers before and five years after mobilized stem cell donation.PMC8919626Bonig HBrauninger SKolpakova ASeifried EReinhardt PNakov RMathieson NDimova-Dobreva MSeidl CHeyn JKoptelova NTsamadou CSchrezenmeier HfalseSuperior physical and mental health of healthy volunteers before and five years after mobilized stem cell donation.<h4>Background</h4>Safety, tolerability and efficacy of granulocyte colony-stimulating factor (G-CSF) for mobilization of hematopoietic stem and progenitor cells (HSPCs) from healthy donors have been conclusively demonstrated. This explicitly includes, albeit for smaller cohorts and shorter observation periods, biosimilar G-CSFs. HSPC donation is non-remunerated, its sole reward being "warm glow", hence harm to donors must be avoided with maximal certitude. To ascertain, therefore, long-term physical and mental health effects of HSPC donation, a cohort of G-CSF mobilized donors was followed longitudinally.<h4>Methods</h4>We enrolled 245 healthy volunteers in this bi-centric long-term surveillance study. 244 healthy volunteers began mobilization with twice-daily Sandoz biosimilar filgrastim2022-01-01T00:00:00Z2022 Mar2026-06-01T02:37:17.797Z2024-10-16T15:09:05.276ZS-EPMC89196263528767210.1186/s12967-022-03322-w