{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang X"],"funding":["NIAID NIH HHS","NCI NIH HHS"],"pagination":["106-12"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8919957"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Topological defects in liquid crystals (LCs) have been widely used to organize colloidal dispersions and template polymerization, leading to a range of assemblies, elastomers and gels. However, little is understood about molecular-level assembly processes within defects. Here, we report that nanoscopic environments defined by LC topological defects can selectively trigger processes of molecular self-assembly. By using fluorescence microscopy, cryogenic transmission electron microscopy and super-resolution optical microscopy, we observed signatures of molecular self-assembly of amphiphilic molecules in topological defects, including cooperativity, reversibility and controlled growth. We also show that nanoscopic o-rings synthesized from Saturn-ring disclinations and other molecular assembli"],"journal":["Nature materials"],"pubmed_title":["Topological defects in liquid crystals as templates for molecular self-assembly."],"pmcid":["PMC8919957"],"funding_grant_id":["R01 CA108467","AI092004","CA108467","R21 AI092004"],"pubmed_authors":["Bukusoglu E","Miller DS","Abbott NL","Wang X","de Pablo JJ"],"additional_accession":[]},"is_claimable":false,"name":"Topological defects in liquid crystals as templates for molecular self-assembly.","description":"Topological defects in liquid crystals (LCs) have been widely used to organize colloidal dispersions and template polymerization, leading to a range of assemblies, elastomers and gels. However, little is understood about molecular-level assembly processes within defects. Here, we report that nanoscopic environments defined by LC topological defects can selectively trigger processes of molecular self-assembly. By using fluorescence microscopy, cryogenic transmission electron microscopy and super-resolution optical microscopy, we observed signatures of molecular self-assembly of amphiphilic molecules in topological defects, including cooperativity, reversibility and controlled growth. We also show that nanoscopic o-rings synthesized from Saturn-ring disclinations and other molecular assembli","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jan","modification":"2025-04-04T20:38:37.471Z","creation":"2025-04-04T20:38:37.471Z"},"accession":"S-EPMC8919957","cross_references":{"pubmed":["26390324"],"doi":["10.1038/nmat4421"]}}