biostudies-literatureRiel AMSDivision of ChemistryUniversity of California, San DiegoNational Institute of General Medical SciencesNIGMS NIH HHSNational Science Foundation1378-1381https://www.ebi.ac.uk/biostudies/studies/S-EPMC8919959biostudies-literatureUnknown58(9)Recent results indicate a halogen bond donor is strengthened through direct interaction with a hydrogen bond to the electron-rich belt of the halogen. Here, this Hydrogen Bond enhanced Halogen Bond (HBeXB) plays a clear role in a catalyst. Our HBeXB catalyst improves product conversion in a halide abstraction reaction over a traditional halogen bonding derivative.Chemical communications (Cambridge, England)Halogen bonding organocatalysis enhanced through intramolecular hydrogen bonds.PMC8919959P20 GM103546P20GM103546MRI CHE-1337908ACI-1548562TG-PHY210099CAREER CHE-1555324Berryman OBDecato DARiel AMSSun JfalseHalogen bonding organocatalysis enhanced through intramolecular hydrogen bonds.Recent results indicate a halogen bond donor is strengthened through direct interaction with a hydrogen bond to the electron-rich belt of the halogen. Here, this Hydrogen Bond enhanced Halogen Bond (HBeXB) plays a clear role in a catalyst. Our HBeXB catalyst improves product conversion in a halide abstraction reaction over a traditional halogen bonding derivative.2022-01-01T00:00:00Z2022 Jan2025-04-22T06:31:18.637Z2025-04-05T21:47:03.083ZS-EPMC89199593498973210.1039/d1cc05475a