{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Radin I"],"funding":["NSF Center for Engineering Mechanobiology","Howard Hughes Medical Institute","HHMI-Simons Faculty Scholar","National Science Foundation"],"pagination":["2015893"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8920221"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["The PIEZO protein family was first described in animals where these mechanosensitive calcium channels perform numerous essential functions, including the perception of light touch, shear, and compressive forces. PIEZO homologs are present in most eukaryotic lineages and recently we reported that two PIEZO homologs from moss <i>Physcomitrium patens</i> localize to the vacuolar membrane and modulate its morphology in tip-growing caulonemal cells. Here we show that predicted structures of both <i>Pp</i>PIEZO1 and <i>Pp</i>PIEZO2 are very similar to that of mouse Piezo2. Furthermore, we show that both moss <i>PIEZO</i> genes are ubiquitously expressed in moss vegetative tissues and that they are not required for normal vacuolar pH or intracellular osmotic potential. These results suggest that "],"journal":["Plant signaling & behavior"],"pubmed_title":["Moss PIEZO homologs have a conserved structure, are ubiquitously expressed, and do not affect general vacuole function."],"pmcid":["PMC8920221"],"funding_grant_id":["CMMI 1548571","55108530"],"pubmed_authors":["Radin I","Haswell ES","Richardson RA"],"additional_accession":[]},"is_claimable":false,"name":"Moss PIEZO homologs have a conserved structure, are ubiquitously expressed, and do not affect general vacuole function.","description":"The PIEZO protein family was first described in animals where these mechanosensitive calcium channels perform numerous essential functions, including the perception of light touch, shear, and compressive forces. PIEZO homologs are present in most eukaryotic lineages and recently we reported that two PIEZO homologs from moss <i>Physcomitrium patens</i> localize to the vacuolar membrane and modulate its morphology in tip-growing caulonemal cells. Here we show that predicted structures of both <i>Pp</i>PIEZO1 and <i>Pp</i>PIEZO2 are very similar to that of mouse Piezo2. Furthermore, we show that both moss <i>PIEZO</i> genes are ubiquitously expressed in moss vegetative tissues and that they are not required for normal vacuolar pH or intracellular osmotic potential. These results suggest that ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-06-01T02:28:47.237Z","creation":"2024-10-16T14:47:29.853Z"},"accession":"S-EPMC8920221","cross_references":{"pubmed":["34951344"],"doi":["10.1080/15592324.2021.2015893"]}}