{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Srinivasan AR"],"funding":["National Institute of Neurological Disorders and Stroke","NINDS NIH HHS","National Institute of General Medical Sciences","NIGMS NIH HHS","NIH HHS"],"pagination":["e13559"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8920459"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(3)"],"pubmed_abstract":["Aging is a risk factor for neurodegenerative disease, but precise mechanisms that influence this relationship are still under investigation. Work in Drosophila melanogaster identified the microRNA miR-34 as a modifier of aging and neurodegeneration in the brain. MiR-34 mutants present aspects of early aging, including reduced lifespan, neurodegeneration, and a buildup of the repressive histone mark H3K27me3. To better understand how miR-34 regulated pathways contribute to age-associated phenotypes in the brain, here we transcriptionally profiled the miR-34 mutant brain. This identified that genes associated with translation are dysregulated in the miR-34 mutant. The brains of these animals show increased translation activity, accumulation of protein aggregation markers, and altered autopha"],"journal":["Aging cell"],"pubmed_title":["Loss of miR-34 in Drosophila dysregulates protein translation and protein turnover in the aging brain."],"pmcid":["PMC8920459"],"funding_grant_id":["T32‐GM007229","R35‐NS097275","R35 NS097275","T32 GM007229","P40 OD018537"],"pubmed_authors":["Srinivasan AR","Bonini NM","Tran TT"],"additional_accession":[]},"is_claimable":false,"name":"Loss of miR-34 in Drosophila dysregulates protein translation and protein turnover in the aging brain.","description":"Aging is a risk factor for neurodegenerative disease, but precise mechanisms that influence this relationship are still under investigation. Work in Drosophila melanogaster identified the microRNA miR-34 as a modifier of aging and neurodegeneration in the brain. MiR-34 mutants present aspects of early aging, including reduced lifespan, neurodegeneration, and a buildup of the repressive histone mark H3K27me3. To better understand how miR-34 regulated pathways contribute to age-associated phenotypes in the brain, here we transcriptionally profiled the miR-34 mutant brain. This identified that genes associated with translation are dysregulated in the miR-34 mutant. The brains of these animals show increased translation activity, accumulation of protein aggregation markers, and altered autopha","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-07-14T14:22:14.4Z","creation":"2025-04-04T07:44:36.469Z"},"accession":"S-EPMC8920459","cross_references":{"pubmed":["35166006"],"doi":["10.1111/acel.13559"]}}