biostudies-literatureSrinivasan ARNational Institute of Neurological Disorders and StrokeNINDS NIH HHSNational Institute of General Medical SciencesNIGMS NIH HHSNIH HHSe13559https://www.ebi.ac.uk/biostudies/studies/S-EPMC8920459biostudies-literatureUnknown21(3)Aging is a risk factor for neurodegenerative disease, but precise mechanisms that influence this relationship are still under investigation. Work in Drosophila melanogaster identified the microRNA miR-34 as a modifier of aging and neurodegeneration in the brain. MiR-34 mutants present aspects of early aging, including reduced lifespan, neurodegeneration, and a buildup of the repressive histone mark H3K27me3. To better understand how miR-34 regulated pathways contribute to age-associated phenotypes in the brain, here we transcriptionally profiled the miR-34 mutant brain. This identified that genes associated with translation are dysregulated in the miR-34 mutant. The brains of these animals show increased translation activity, accumulation of protein aggregation markers, and altered autophaAging cellLoss of miR-34 in Drosophila dysregulates protein translation and protein turnover in the aging brain.PMC8920459T32‐GM007229R35‐NS097275R35 NS097275T32 GM007229P40 OD018537Srinivasan ARBonini NMTran TTfalseLoss of miR-34 in Drosophila dysregulates protein translation and protein turnover in the aging brain.Aging is a risk factor for neurodegenerative disease, but precise mechanisms that influence this relationship are still under investigation. Work in Drosophila melanogaster identified the microRNA miR-34 as a modifier of aging and neurodegeneration in the brain. MiR-34 mutants present aspects of early aging, including reduced lifespan, neurodegeneration, and a buildup of the repressive histone mark H3K27me3. To better understand how miR-34 regulated pathways contribute to age-associated phenotypes in the brain, here we transcriptionally profiled the miR-34 mutant brain. This identified that genes associated with translation are dysregulated in the miR-34 mutant. The brains of these animals show increased translation activity, accumulation of protein aggregation markers, and altered autopha2022-01-01T00:00:00Z2022 Mar2026-07-14T14:22:14.4Z2025-04-04T07:44:36.469ZS-EPMC89204593516600610.1111/acel.13559