biostudies-literatureUnknown9Zanoni MAldehyde dehydrogenases (ALDHs) are a family of detoxifying enzymes often upregulated in cancer cells and associated with therapeutic resistance. In humans, the ALDH family comprises 19 isoenzymes active in the majority of mammalian tissues. Each ALDH isoform has a specific differential expression pattern and most of them have individual functional roles in cancer. ALDHs are overexpressed in subpopulations of cancer cells with stem-like features, where they are involved in several processes including cellular proliferation, differentiation, detoxification and survival, participating in lipids and amino acid metabolism and retinoic acid synthesis. In particular, ALDH enzymes protect cancer cells by metabolizing toxic aldehydes in less reactive and more soluble carboxylic acids. High metabolFrontiers in medicine795762https://www.ebi.ac.uk/biostudies/studies/S-EPMC8920988biostudies-literatureEmerging Roles of Aldehyde Dehydrogenase Isoforms in Anti-cancer Therapy Resistance.PMC8920988Bravaccini SZanoni MArienti CFabbri FfalseEmerging Roles of Aldehyde Dehydrogenase Isoforms in Anti-cancer Therapy Resistance.Aldehyde dehydrogenases (ALDHs) are a family of detoxifying enzymes often upregulated in cancer cells and associated with therapeutic resistance. In humans, the ALDH family comprises 19 isoenzymes active in the majority of mammalian tissues. Each ALDH isoform has a specific differential expression pattern and most of them have individual functional roles in cancer. ALDHs are overexpressed in subpopulations of cancer cells with stem-like features, where they are involved in several processes including cellular proliferation, differentiation, detoxification and survival, participating in lipids and amino acid metabolism and retinoic acid synthesis. In particular, ALDH enzymes protect cancer cells by metabolizing toxic aldehydes in less reactive and more soluble carboxylic acids. High metabol2022-01-01T00:00:00Z20222025-04-18T21:01:52.192Z2024-11-20T22:35:58.025ZS-EPMC89209883529984010.3389/fmed.2022.795762