{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yakushev I"],"funding":["Technische Universität München","Deutsche Forschungsgemeinschaft"],"pagination":["1288-1297"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8921091"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["49(4)"],"pubmed_abstract":["<h4>Purpose</h4>Inter-subject covariance of regional 18F-fluorodeoxyglucose (FDG) PET measures (FDG<sub>cov</sub>) as proxy of brain connectivity has been gaining an increasing acceptance in the community. Yet, it is still unclear to what extent FDG<sub>cov</sub> is underlied by actual structural connectivity via white matter fiber tracts. In this study, we quantified the degree of spatial overlap between FDG<sub>cov</sub> and structural connectivity networks.<h4>Methods</h4>We retrospectively analyzed neuroimaging data from 303 subjects, both patients with suspected neurodegenerative disorders and healthy individuals. For each subject, structural magnetic resonance, diffusion tensor imaging, and FDG-PET data were available. The images were spatially normalized to a standard space and segmented into 62 anatomical regions using a probabilistic atlas. Sparse inverse covariance estimation was employed to estimate FDG<sub>cov</sub>. Structural connectivity was measured by streamline tractography through fiber assignment by continuous tracking.<h4>Results</h4>For the whole brain, 55% of detected connections were found to be convergent, i.e., present in both FDG<sub>cov</sub> and structural networks. This metric for random networks was significantly lower, i.e., 12%. Convergent were 80% of intralobe connections and only 30% of interhemispheric interlobe connections.<h4>Conclusion</h4>Structural connectivity via white matter fiber tracts is a relevant substrate of FDG<sub>cov</sub>, underlying around a half of connections at the whole brain level. Short-range white matter tracts appear to be a major substrate of intralobe FDG<sub>cov</sub> connections."],"journal":["European journal of nuclear medicine and molecular imaging"],"pubmed_title":["Mapping covariance in brain FDG uptake to structural connectivity."],"pmcid":["PMC8921091"],"funding_grant_id":["YA 373/3-1"],"pubmed_authors":["Wang M","Lizarraga A","Grimmer T","Yakushev I","Savio A","Ripp I","Schutte M","Hedderich DM","Bogdanovic B","Shi K","Diehl-Schmid J"],"additional_accession":[]},"is_claimable":false,"name":"Mapping covariance in brain FDG uptake to structural connectivity.","description":"<h4>Purpose</h4>Inter-subject covariance of regional 18F-fluorodeoxyglucose (FDG) PET measures (FDG<sub>cov</sub>) as proxy of brain connectivity has been gaining an increasing acceptance in the community. Yet, it is still unclear to what extent FDG<sub>cov</sub> is underlied by actual structural connectivity via white matter fiber tracts. In this study, we quantified the degree of spatial overlap between FDG<sub>cov</sub> and structural connectivity networks.<h4>Methods</h4>We retrospectively analyzed neuroimaging data from 303 subjects, both patients with suspected neurodegenerative disorders and healthy individuals. For each subject, structural magnetic resonance, diffusion tensor imaging, and FDG-PET data were available. The images were spatially normalized to a standard space and segmented into 62 anatomical regions using a probabilistic atlas. Sparse inverse covariance estimation was employed to estimate FDG<sub>cov</sub>. Structural connectivity was measured by streamline tractography through fiber assignment by continuous tracking.<h4>Results</h4>For the whole brain, 55% of detected connections were found to be convergent, i.e., present in both FDG<sub>cov</sub> and structural networks. This metric for random networks was significantly lower, i.e., 12%. Convergent were 80% of intralobe connections and only 30% of interhemispheric interlobe connections.<h4>Conclusion</h4>Structural connectivity via white matter fiber tracts is a relevant substrate of FDG<sub>cov</sub>, underlying around a half of connections at the whole brain level. Short-range white matter tracts appear to be a major substrate of intralobe FDG<sub>cov</sub> connections.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T13:21:50.653Z","creation":"2025-04-04T13:21:50.653Z"},"accession":"S-EPMC8921091","cross_references":{"pubmed":["34677627"],"doi":["10.1007/s00259-021-05590-y"]}}