{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["61(3)"],"submitter":["Slater T"],"funding":["Nottingham Trent University"],"pubmed_abstract":["<h4>Purpose</h4>This study aimed to assess the effects of consuming a very-low-energy placebo breakfast on subsequent appetite and lunch energy intake.<h4>Methods</h4>Fourteen healthy males consumed water-only (WAT), very-low-energy, viscous placebo (containing water, low-calorie flavoured squash, and xanthan gum; ~ 16 kcal; PLA), and whole-food (~ 573 kcal; FOOD) breakfasts in a randomised order. Subjects were blinded to the energy content of PLA and specific study aims. Venous blood samples were collected pre-breakfast, 60- and 180-min post-breakfast to assess plasma acylated ghrelin and peptide tyrosine tyrosine concentrations. Subjective appetite was measured regularly, and energy intake was assessed at an ad libitum lunch meal 195-min post-breakfast.<h4>Results</h4>Lunch energy intake was lower during FOOD compared to WAT (P < 0.05), with no further differences between trials (P ≥ 0.132). Cumulative energy intake (breakfast plus lunch) was lower during PLA (1078 ± 274 kcal) and WAT (1093 ± 249 kcal), compared to FOOD (1554 ± 301 kcal; P < 0.001). Total area under the curve (AUC) for hunger, desire to eat and prospective food consumption were lower, and fullness was greater during PLA and FOOD compared to WAT (P < 0.05). AUC for hunger was lower during FOOD compared to PLA (P < 0.05). During FOOD, acylated ghrelin was suppressed compared to PLA and WAT at 60 min (P < 0.05), with no other hormonal differences between trials (P ≥ 0.071).<h4>Conclusion</h4>Consuming a very-low-energy placebo breakfast does not alter energy intake at lunch but may reduce cumulative energy intake across breakfast and lunch and attenuate elevations in subjective appetite associated with breakfast omission.<h4>Trial registration</h4>NCT04735783, 2nd February 2021, retrospectively registered."],"journal":["European journal of nutrition"],"pagination":["1319-1330"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8921169"],"repository":["biostudies-literature"],"pubmed_title":["Effect of the perception of breakfast consumption on subsequent appetite and energy intake in healthy males."],"pmcid":["PMC8921169"],"pubmed_authors":["Mode WJA","James RM","Sale C","Hough J","Slater T","Clayton DJ","James LJ"],"additional_accession":[]},"is_claimable":false,"name":"Effect of the perception of breakfast consumption on subsequent appetite and energy intake in healthy males.","description":"<h4>Purpose</h4>This study aimed to assess the effects of consuming a very-low-energy placebo breakfast on subsequent appetite and lunch energy intake.<h4>Methods</h4>Fourteen healthy males consumed water-only (WAT), very-low-energy, viscous placebo (containing water, low-calorie flavoured squash, and xanthan gum; ~ 16 kcal; PLA), and whole-food (~ 573 kcal; FOOD) breakfasts in a randomised order. Subjects were blinded to the energy content of PLA and specific study aims. Venous blood samples were collected pre-breakfast, 60- and 180-min post-breakfast to assess plasma acylated ghrelin and peptide tyrosine tyrosine concentrations. Subjective appetite was measured regularly, and energy intake was assessed at an ad libitum lunch meal 195-min post-breakfast.<h4>Results</h4>Lunch energy intake was lower during FOOD compared to WAT (P < 0.05), with no further differences between trials (P ≥ 0.132). Cumulative energy intake (breakfast plus lunch) was lower during PLA (1078 ± 274 kcal) and WAT (1093 ± 249 kcal), compared to FOOD (1554 ± 301 kcal; P < 0.001). Total area under the curve (AUC) for hunger, desire to eat and prospective food consumption were lower, and fullness was greater during PLA and FOOD compared to WAT (P < 0.05). AUC for hunger was lower during FOOD compared to PLA (P < 0.05). During FOOD, acylated ghrelin was suppressed compared to PLA and WAT at 60 min (P < 0.05), with no other hormonal differences between trials (P ≥ 0.071).<h4>Conclusion</h4>Consuming a very-low-energy placebo breakfast does not alter energy intake at lunch but may reduce cumulative energy intake across breakfast and lunch and attenuate elevations in subjective appetite associated with breakfast omission.<h4>Trial registration</h4>NCT04735783, 2nd February 2021, retrospectively registered.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-06-19T03:19:06.079Z","creation":"2025-02-19T02:01:56.191Z"},"accession":"S-EPMC8921169","cross_references":{"pubmed":["34766208"],"doi":["10.1007/s00394-021-02727-5"]}}