{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Holden S"],"funding":["Office of Extramural Research, National Institutes of Health"],"pubmed_abstract":["Mice expressing human amyloid precursor protein (APP) containing the dominant Swedish and Iberian mutations (<i>App<sup>NL-F</sup></i> ) or also Arctic mutation (<i>App<sup>NL-G-F</sup></i> ) show neuropathology and hippocampus-dependent cognitive impairments pertinent to Alzheimer's disease (AD) in mouse models at 18 and 6 months of age, respectively. Apolipoprotein E, involved in cholesterol metabolism, plays an important role in maintaining the brain. There are three human apolipoprotein E isoforms: E2, E3, and E4. Compared to E3, E4 increases while E2 protects against AD risk. At 6 months of age, prior to the onset of plaque pathology, E3, but not E4, protected against hAPP/Aβ-induced impairments in spatial memory retention in the Morris water maze. However, these earlier studies were "],"journal":["Frontiers in aging neuroscience"],"pagination":["767558"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8922030"],"repository":["biostudies-literature"],"pubmed_title":["Apolipoprotein E Isoform-Dependent Effects on Human Amyloid Precursor Protein/Aβ-Induced Behavioral Alterations and Cognitive Impairments and Insoluble Cortical Aβ42 Levels."],"pmcid":["PMC8922030"],"pubmed_authors":["Torres ERS","Krenik D","Turker MS","Kundu P","Raber J","Sudhakar R","Grygoryev D","Holden S"],"additional_accession":[]},"is_claimable":false,"name":"Apolipoprotein E Isoform-Dependent Effects on Human Amyloid Precursor Protein/Aβ-Induced Behavioral Alterations and Cognitive Impairments and Insoluble Cortical Aβ42 Levels.","description":"Mice expressing human amyloid precursor protein (APP) containing the dominant Swedish and Iberian mutations (<i>App<sup>NL-F</sup></i> ) or also Arctic mutation (<i>App<sup>NL-G-F</sup></i> ) show neuropathology and hippocampus-dependent cognitive impairments pertinent to Alzheimer's disease (AD) in mouse models at 18 and 6 months of age, respectively. Apolipoprotein E, involved in cholesterol metabolism, plays an important role in maintaining the brain. There are three human apolipoprotein E isoforms: E2, E3, and E4. Compared to E3, E4 increases while E2 protects against AD risk. At 6 months of age, prior to the onset of plaque pathology, E3, but not E4, protected against hAPP/Aβ-induced impairments in spatial memory retention in the Morris water maze. However, these earlier studies were ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-29T11:03:32.505Z","creation":"2025-04-06T19:47:50.823Z"},"accession":"S-EPMC8922030","cross_references":{"pubmed":["35299942"],"doi":["10.3389/fnagi.2022.767558"]}}