biostudies-literatureUnknown14Holden SOffice of Extramural Research, National Institutes of HealthMice expressing human amyloid precursor protein (APP) containing the dominant Swedish and Iberian mutations (<i>App^NL-F</i> ) or also Arctic mutation (<i>App^NL-G-F</i> ) show neuropathology and hippocampus-dependent cognitive impairments pertinent to Alzheimer's disease (AD) in mouse models at 18 and 6 months of age, respectively. Apolipoprotein E, involved in cholesterol metabolism, plays an important role in maintaining the brain. There are three human apolipoprotein E isoforms: E2, E3, and E4. Compared to E3, E4 increases while E2 protects against AD risk. At 6 months of age, prior to the onset of plaque pathology, E3, but not E4, protected against hAPP/Aβ-induced impairments in spatial memory retention in the Morris water maze. However, these earlier studies were Frontiers in aging neuroscience767558https://www.ebi.ac.uk/biostudies/studies/S-EPMC8922030biostudies-literatureApolipoprotein E Isoform-Dependent Effects on Human Amyloid Precursor Protein/Aβ-Induced Behavioral Alterations and Cognitive Impairments and Insoluble Cortical Aβ42 Levels.PMC8922030Torres ERSKrenik DTurker MSKundu PRaber JSudhakar RGrygoryev DHolden SfalseApolipoprotein E Isoform-Dependent Effects on Human Amyloid Precursor Protein/Aβ-Induced Behavioral Alterations and Cognitive Impairments and Insoluble Cortical Aβ42 Levels.Mice expressing human amyloid precursor protein (APP) containing the dominant Swedish and Iberian mutations (<i>App^NL-F</i> ) or also Arctic mutation (<i>App^NL-G-F</i> ) show neuropathology and hippocampus-dependent cognitive impairments pertinent to Alzheimer's disease (AD) in mouse models at 18 and 6 months of age, respectively. Apolipoprotein E, involved in cholesterol metabolism, plays an important role in maintaining the brain. There are three human apolipoprotein E isoforms: E2, E3, and E4. Compared to E3, E4 increases while E2 protects against AD risk. At 6 months of age, prior to the onset of plaque pathology, E3, but not E4, protected against hAPP/Aβ-induced impairments in spatial memory retention in the Morris water maze. However, these earlier studies were 2022-01-01T00:00:00Z20222025-04-29T11:03:32.505Z2025-04-06T19:47:50.823ZS-EPMC89220303529994210.3389/fnagi.2022.767558