{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ihewulezi C"],"funding":["NIDCR NIH HHS","National Institute of Dental and Craniofacial Research"],"pagination":["e23447"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8922215"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["59(10)"],"pubmed_abstract":["The neural crest is a dynamic embryonic structure that plays a major role in the formation of the vertebrate craniofacial skeleton. Neural crest formation is regulated by a complex sequence of events directed by a network of transcription factors working in concert with chromatin modifiers. The high mobility group nucleosome binding protein 1 (Hmgn1) is a nonhistone chromatin architectural protein, associated with transcriptionally active chromatin. Here we report the expression and function of Hmgn1 during Xenopus neural crest and craniofacial development. Hmgn1 is broadly expressed at the gastrula and neurula stages, and is enriched in the head region at the tailbud stage, especially in the eyes and the pharyngeal arches. Hmgn1 knockdown affected the expression of several neural crest sp"],"journal":["Genesis (New York, N.Y. : 2000)"],"pubmed_title":["Function of chromatin modifier Hmgn1 during neural crest and craniofacial development."],"pmcid":["PMC8922215"],"funding_grant_id":["R01 DE025468","R01DE025468"],"pubmed_authors":["Saint-Jeannet JP","Ihewulezi C"],"additional_accession":[]},"is_claimable":false,"name":"Function of chromatin modifier Hmgn1 during neural crest and craniofacial development.","description":"The neural crest is a dynamic embryonic structure that plays a major role in the formation of the vertebrate craniofacial skeleton. Neural crest formation is regulated by a complex sequence of events directed by a network of transcription factors working in concert with chromatin modifiers. The high mobility group nucleosome binding protein 1 (Hmgn1) is a nonhistone chromatin architectural protein, associated with transcriptionally active chromatin. Here we report the expression and function of Hmgn1 during Xenopus neural crest and craniofacial development. Hmgn1 is broadly expressed at the gastrula and neurula stages, and is enriched in the head region at the tailbud stage, especially in the eyes and the pharyngeal arches. Hmgn1 knockdown affected the expression of several neural crest sp","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-04T12:04:31.746Z","creation":"2025-04-04T12:04:31.746Z"},"accession":"S-EPMC8922215","cross_references":{"pubmed":["34478234"],"doi":["10.1002/dvg.23447"]}}