{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li H"],"funding":["National Natural Science Foundation of China"],"pagination":["e108544"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8922252"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(6)"],"pubmed_abstract":["Since numerous RNAs and RBPs prevalently localize to active chromatin regions, many RNA-binding proteins (RBPs) may be potential transcriptional regulators. RBPs are generally thought to regulate transcription via noncoding RNAs. Here, we describe a distinct, dual mechanism of transcriptional regulation by the previously uncharacterized tRNA-modifying enzyme, hTrmt13. On one hand, hTrmt13 acts in the cytoplasm to catalyze 2'-O-methylation of tRNAs, thus regulating translation in a manner depending on its tRNA-modification activity. On the other hand, nucleus-localized hTrmt13 directly binds DNA as a transcriptional co-activator of key epithelial-mesenchymal transition factors, thereby promoting cell migration independent of tRNA-modification activity. These dual functions of hTrmt13 are mu"],"journal":["The EMBO journal"],"pubmed_title":["A dual role of human tRNA methyltransferase hTrmt13 in regulating translation and transcription."],"pmcid":["PMC8922252"],"funding_grant_id":["31770842","91940302","31971230","32022040","31870811"],"pubmed_authors":["Huang ZX","Li H","Li J","Zeng QY","Dong H","Xiong QP","Xu B","Yang WQ","Li CT","Wang ED","Liu RJ"],"additional_accession":[]},"is_claimable":false,"name":"A dual role of human tRNA methyltransferase hTrmt13 in regulating translation and transcription.","description":"Since numerous RNAs and RBPs prevalently localize to active chromatin regions, many RNA-binding proteins (RBPs) may be potential transcriptional regulators. RBPs are generally thought to regulate transcription via noncoding RNAs. Here, we describe a distinct, dual mechanism of transcriptional regulation by the previously uncharacterized tRNA-modifying enzyme, hTrmt13. On one hand, hTrmt13 acts in the cytoplasm to catalyze 2'-O-methylation of tRNAs, thus regulating translation in a manner depending on its tRNA-modification activity. On the other hand, nucleus-localized hTrmt13 directly binds DNA as a transcriptional co-activator of key epithelial-mesenchymal transition factors, thereby promoting cell migration independent of tRNA-modification activity. These dual functions of hTrmt13 are mu","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-25T23:00:58.988Z","creation":"2025-02-19T03:58:58.552Z"},"accession":"S-EPMC8922252","cross_references":{"pubmed":["34850409"],"doi":["10.15252/embj.2021108544"]}}