{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Matavele Chissumba R"],"funding":["Henry M. Jackson Foundation","Flanders Department of Foreign Affairs of the Flemish Government"],"pagination":["12"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8922818"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>Human immunodeficiency virus type 1 (HIV-1) causes impairment of T and B cell responses, which begins during the acute phase of infection and is not completely restored by antiretroviral treatment. Regulatory T cell (Tregs) can improve overall disease outcome by controlling chronic inflammation but may also suppress beneficial HIV-1 specific immune responses. We aimed to analyze the profile of Tregs and their correlation with the status of T cells activation, the expression of IL-2 and IFNγ and the profile of HIV-1 specific antibodies response in Mozambican people living chronically with HIV-1 (PLWH-C).<h4>Results</h4>In PLWH-C, the proportion of total Tregs was positively correlated with the proportion of IL-2<sup>+</sup>CD4 T cells (r = 0.647; p = 0.032) and IL-2<sup>+"],"journal":["BMC immunology"],"pubmed_title":["Helios expressing regulatory T cells are correlated with decreased IL-2 producing CD8 T cells and antibody diversity in Mozambican individuals living chronically with HIV-1."],"pmcid":["PMC8922818"],"funding_grant_id":["W81XWH-07-2-0067"],"pubmed_authors":["Eller LA","Ake J","Castiano C","Milazzo M","Magul C","Guiliche O","Schech S","Swann EM","Bhatt N","Capitine I","Massingue C","Viegas E","Machaze A","Hassen Z","Namalamgo E","Polyak CS","Macamo R","Crowell T","Cumbane V","Cavele N","Matimbe D","Kestens L","RV363 Study Group","Nwoga C","Ramgi P","Imbach M","Smith G","Jani I","Li Q","Inhambizo L","Mapossa V","Monteiro V","Matavele Chissumba R","Mutombene M","De Araujo K","Chissumba RM","Macicame I","Mandlate F","Robb ML","Yates A","Manhica E","Enosse M"],"additional_accession":[]},"is_claimable":false,"name":"Helios expressing regulatory T cells are correlated with decreased IL-2 producing CD8 T cells and antibody diversity in Mozambican individuals living chronically with HIV-1.","description":"<h4>Background</h4>Human immunodeficiency virus type 1 (HIV-1) causes impairment of T and B cell responses, which begins during the acute phase of infection and is not completely restored by antiretroviral treatment. Regulatory T cell (Tregs) can improve overall disease outcome by controlling chronic inflammation but may also suppress beneficial HIV-1 specific immune responses. We aimed to analyze the profile of Tregs and their correlation with the status of T cells activation, the expression of IL-2 and IFNγ and the profile of HIV-1 specific antibodies response in Mozambican people living chronically with HIV-1 (PLWH-C).<h4>Results</h4>In PLWH-C, the proportion of total Tregs was positively correlated with the proportion of IL-2<sup>+</sup>CD4 T cells (r = 0.647; p = 0.032) and IL-2<sup>+","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-26T18:28:05.755Z","creation":"2024-11-14T01:49:58.358Z"},"accession":"S-EPMC8922818","cross_references":{"pubmed":["35287587"],"doi":["10.1186/s12865-022-00487-3"]}}