biostudies-literatureMatavele Chissumba RHenry M. Jackson FoundationFlanders Department of Foreign Affairs of the Flemish Government12https://www.ebi.ac.uk/biostudies/studies/S-EPMC8922818biostudies-literatureUnknown23(1)<h4>Background</h4>Human immunodeficiency virus type 1 (HIV-1) causes impairment of T and B cell responses, which begins during the acute phase of infection and is not completely restored by antiretroviral treatment. Regulatory T cell (Tregs) can improve overall disease outcome by controlling chronic inflammation but may also suppress beneficial HIV-1 specific immune responses. We aimed to analyze the profile of Tregs and their correlation with the status of T cells activation, the expression of IL-2 and IFNγ and the profile of HIV-1 specific antibodies response in Mozambican people living chronically with HIV-1 (PLWH-C).<h4>Results</h4>In PLWH-C, the proportion of total Tregs was positively correlated with the proportion of IL-2⁺CD4 T cells (r = 0.647; p = 0.032) and IL-2<sup>+BMC immunologyHelios expressing regulatory T cells are correlated with decreased IL-2 producing CD8 T cells and antibody diversity in Mozambican individuals living chronically with HIV-1.PMC8922818W81XWH-07-2-0067Eller LAAke JCastiano CMilazzo MMagul CGuiliche OSchech SSwann EMBhatt NCapitine IMassingue CViegas EMachaze AHassen ZNamalamgo EPolyak CSMacamo RCrowell TCumbane VCavele NMatimbe DKestens LRV363 Study GroupNwoga CRamgi PImbach MSmith GJani ILi QInhambizo LMapossa VMonteiro VMatavele Chissumba RMutombene MDe Araujo KChissumba RMMacicame IMandlate FRobb MLYates AManhica EEnosse MfalseHelios expressing regulatory T cells are correlated with decreased IL-2 producing CD8 T cells and antibody diversity in Mozambican individuals living chronically with HIV-1.<h4>Background</h4>Human immunodeficiency virus type 1 (HIV-1) causes impairment of T and B cell responses, which begins during the acute phase of infection and is not completely restored by antiretroviral treatment. Regulatory T cell (Tregs) can improve overall disease outcome by controlling chronic inflammation but may also suppress beneficial HIV-1 specific immune responses. We aimed to analyze the profile of Tregs and their correlation with the status of T cells activation, the expression of IL-2 and IFNγ and the profile of HIV-1 specific antibodies response in Mozambican people living chronically with HIV-1 (PLWH-C).<h4>Results</h4>In PLWH-C, the proportion of total Tregs was positively correlated with the proportion of IL-2⁺CD4 T cells (r = 0.647; p = 0.032) and IL-2<sup>+2022-01-01T00:00:00Z2022 Mar2025-04-26T18:28:05.755Z2024-11-14T01:49:58.358ZS-EPMC89228183528758710.1186/s12865-022-00487-3