{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(3)"],"submitter":["Mestiri S"],"funding":["Université de Tunis","Ministry of Higher Education and Scientific Research"],"pubmed_abstract":["<h4>Background</h4>The single nucleotide polymorphisms (SNPs) of the dopamine D3 receptor (DRD3), the CUB and sushi multiple domains 1 (CSMD1) and the neuregulin 1 (NRG1) genes were used to study the genetic diversity and affinity among North African populations and to examine their genetic relationships in worldwide populations.<h4>Methods</h4>The rs3773678, rs3732783 and rs6280 SNPs of the DRD3 gene located on chromosome 3, the rs10108270 SNP of the CSMD1 gene and the rs383632, rs385396 and rs1462906 SNPs of the NRG1 gene located on chromosome 8 were analysed in 366 individuals from seven North African populations (Libya, Kairouan, Mehdia, Sousse, Kesra, Smar and Kerkennah).<h4>Results</h4>The low values of F<sub>ST</sub> indicated that only 0.27%-1.65% of the genetic variability was due"],"journal":["Molecular genetics & genomic medicine"],"pagination":["e1871"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8922960"],"repository":["biostudies-literature"],"pubmed_title":["New Insight into the human genetic diversity in North African populations by genotyping of SNPs in DRD3, CSMD1 and NRG1 genes."],"pmcid":["PMC8922960"],"pubmed_authors":["El Kamel S","Cherni L","Mestiri S","Boussetta S","Ben Ammar El Gaaied A","Kidd KK","Pakstis AJ"],"additional_accession":[]},"is_claimable":false,"name":"New Insight into the human genetic diversity in North African populations by genotyping of SNPs in DRD3, CSMD1 and NRG1 genes.","description":"<h4>Background</h4>The single nucleotide polymorphisms (SNPs) of the dopamine D3 receptor (DRD3), the CUB and sushi multiple domains 1 (CSMD1) and the neuregulin 1 (NRG1) genes were used to study the genetic diversity and affinity among North African populations and to examine their genetic relationships in worldwide populations.<h4>Methods</h4>The rs3773678, rs3732783 and rs6280 SNPs of the DRD3 gene located on chromosome 3, the rs10108270 SNP of the CSMD1 gene and the rs383632, rs385396 and rs1462906 SNPs of the NRG1 gene located on chromosome 8 were analysed in 366 individuals from seven North African populations (Libya, Kairouan, Mehdia, Sousse, Kesra, Smar and Kerkennah).<h4>Results</h4>The low values of F<sub>ST</sub> indicated that only 0.27%-1.65% of the genetic variability was due","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-05-10T00:48:05.608Z","creation":"2025-04-05T17:35:27.149Z"},"accession":"S-EPMC8922960","cross_references":{"pubmed":["35128830"],"doi":["10.1002/mgg3.1871"]}}