{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rickelt S"],"funding":["Deutsche Forschungsgemeinschaft","NIDDK NIH HHS","Howard Hughes Medical Institute","NCI NIH HHS","NIH","NIH HHS"],"pagination":["1167-1179"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8923984"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(6)"],"pubmed_abstract":["<h4>Purpose</h4>There is an unmet need for identifying novel biomarkers in Barrett's esophagus that could stratify patients with regards to neoplastic progression. We investigate the expression patterns of extracellular matrix (ECM) molecules in Barrett's esophagus and Barrett's esophagus-related neoplasia, and assess their value as biomarkers for the diagnosis of Barrett's esophagus-related neoplasia and to predict neoplastic progression.<h4>Experimental design</h4>Gene-expression analyses of ECM matrisome gene sets were performed using publicly available data on human Barrett's esophagus, Barrett's esophagus-related dysplasia, esophageal adenocarcinoma (ADCA) and normal esophagus. Immunohistochemical expression of basement membrane (BM) marker agrin (AGRN) and p53 was analyzed in biopsie"],"journal":["Clinical cancer research : an official journal of the American Association for Cancer Research"],"pubmed_title":["Agrin Loss in Barrett's Esophagus-Related Neoplasia and Its Utility as a Diagnostic and Predictive Biomarker."],"pmcid":["PMC8923984"],"funding_grant_id":["K08 DK129824","P30CA014051","T32 CA009216","P30 CA014051","U54 CA163109","T32CA009216","U54-CA163109","RI2408/1-1"],"pubmed_authors":["Zaidi AH","Shroff SG","Odze RD","Mattia AR","Whittaker CA","Condon C","Rickelt S","Yilmaz O","Wu EY","Neyaz A","Hynes RO","Abbruzzese G","Zukerberg L","Patil DT","Deshpande V","Taylor MS","Yilmaz OH","Choi WT","Jobe BA"],"additional_accession":[]},"is_claimable":false,"name":"Agrin Loss in Barrett's Esophagus-Related Neoplasia and Its Utility as a Diagnostic and Predictive Biomarker.","description":"<h4>Purpose</h4>There is an unmet need for identifying novel biomarkers in Barrett's esophagus that could stratify patients with regards to neoplastic progression. We investigate the expression patterns of extracellular matrix (ECM) molecules in Barrett's esophagus and Barrett's esophagus-related neoplasia, and assess their value as biomarkers for the diagnosis of Barrett's esophagus-related neoplasia and to predict neoplastic progression.<h4>Experimental design</h4>Gene-expression analyses of ECM matrisome gene sets were performed using publicly available data on human Barrett's esophagus, Barrett's esophagus-related dysplasia, esophageal adenocarcinoma (ADCA) and normal esophagus. Immunohistochemical expression of basement membrane (BM) marker agrin (AGRN) and p53 was analyzed in biopsie","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-05-29T16:10:46.156Z","creation":"2025-04-19T05:57:12.173Z"},"accession":"S-EPMC8923984","cross_references":{"pubmed":["34785582"],"doi":["10.1158/1078-0432.ccr-21-2822","10.1158/1078-0432.CCR-21-2822"]}}