biostudies-literatureWang YNational Natural Science Foundation of ChinaChina Postdoctoral Science FoundationHeilongjiang Provincial Postdoctoral Science Foundation809747https://www.ebi.ac.uk/biostudies/studies/S-EPMC8924052biostudies-literatureUnknown10Bladder cancer (BC) is a highly prevalent cancer form of the genitourinary system; however, the effective biomarkers are still ambiguous and deserve deeper investigation. Long non-coding RNA (lncRNA) occupies a prominent position in tumor biology and immunology, and ferroptosis-related genes participate in regulatory processes of cancer. In this study, 538 differentially expressed ferroptosis-related lncRNAs were identified from the The Cancer Genome Atlas database through co-expression method and differential expression analysis. Then, the samples involved were equally and randomly divided into two cohorts for the construction of gene model and accuracy verification. Subsequently, a prediction model containing five ferroptosis-related lncRNAs was constructed by LASSO and Cox regression anFrontiers in cell and developmental biologyDevelopment and Validation of Ferroptosis-Related LncRNA Biomarker in Bladder Carcinoma.PMC89240522021T140170Li GLiu XYin HChen JWang SWang YZhang SBai YfalseDevelopment and Validation of Ferroptosis-Related LncRNA Biomarker in Bladder Carcinoma.Bladder cancer (BC) is a highly prevalent cancer form of the genitourinary system; however, the effective biomarkers are still ambiguous and deserve deeper investigation. Long non-coding RNA (lncRNA) occupies a prominent position in tumor biology and immunology, and ferroptosis-related genes participate in regulatory processes of cancer. In this study, 538 differentially expressed ferroptosis-related lncRNAs were identified from the The Cancer Genome Atlas database through co-expression method and differential expression analysis. Then, the samples involved were equally and randomly divided into two cohorts for the construction of gene model and accuracy verification. Subsequently, a prediction model containing five ferroptosis-related lncRNAs was constructed by LASSO and Cox regression an2022-01-01T00:00:00Z20222025-06-01T00:39:12.325Z2025-06-01T00:39:12.325ZS-EPMC89240523530994510.3389/fcell.2022.809747