{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang H"],"funding":["Natural Science Foundation of Tianjin City","National Natural Science Foundation of China"],"pagination":["850943"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8924059"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["<h4>Background</h4>Pyroptosis is a new type of programmed cell death, accompanied by an intense inflammatory response. Previous studies have shown that pyroptosis can modify long-chain non-coding RNA (lncRNA), thereby affecting the occurrence and progression of tumors. However, the underlying role of pyroptosis-related lncRNA in lung adenocarcinoma (LUAD) remains to be elucidated. Therefore, the purpose of our study was to evaluate the prognostic value of pyrolysis-related lncRNA in patients with LUAD.<h4>Methods</h4>A total of 454 LUAD samples were downloaded from The Cancer Genome Atlas (TCGA) database. Pearson's correlation coefficient was used to identify the pyroptosis-related lncRNAs. Unsupervised consensus clustering was used to identify the various LUAD molecular subtypes. A least absolute shrinkage and selection operator (LASSO) analysis was conducted to construct a prognostic signature.<h4>Results</h4>An 11-lncRNA prognostic signature out of 19 identified pyroptosis-related prognostic lncRNAs was constructed. The patients with LUAD were divided into low-risk and high-risk groups. Patients in the high-risk group had higher score values and mortality. The immune score, stromal score, and estimate score were lower in the high-risk group. The risk score was an independent predictor for OS in multivariate Cox regression analyses (HR > 1, p < 0.01). BTLA, PD-1, PD-L1, CTLA, and CD47 were lower expressed in the high-risk group.<h4>Conclusions</h4>Our study identified an 11-pyroptosis-related lncRNA signature. These findings could further clarify the role of pyroptosis in LUAD and guide the prognosis and individualized treatment of patients."],"journal":["Frontiers in oncology"],"pubmed_title":["Pyroptosis-Related LncRNA Signatures Correlate With Lung Adenocarcinoma Prognosis."],"pmcid":["PMC8924059"],"funding_grant_id":["19YFZCSY00040, 19JCYBJC27000","82072595, 82172569, 81773207 , and 61973232"],"pubmed_authors":["Liu H","Pan Z","Shi R","Liu M","Chen J","Huang H","Zhang H","Su L","Zhu G","Shi Z","Chen C","Li Y","Zhang Z","Cao P"],"additional_accession":[]},"is_claimable":false,"name":"Pyroptosis-Related LncRNA Signatures Correlate With Lung Adenocarcinoma Prognosis.","description":"<h4>Background</h4>Pyroptosis is a new type of programmed cell death, accompanied by an intense inflammatory response. Previous studies have shown that pyroptosis can modify long-chain non-coding RNA (lncRNA), thereby affecting the occurrence and progression of tumors. However, the underlying role of pyroptosis-related lncRNA in lung adenocarcinoma (LUAD) remains to be elucidated. Therefore, the purpose of our study was to evaluate the prognostic value of pyrolysis-related lncRNA in patients with LUAD.<h4>Methods</h4>A total of 454 LUAD samples were downloaded from The Cancer Genome Atlas (TCGA) database. Pearson's correlation coefficient was used to identify the pyroptosis-related lncRNAs. Unsupervised consensus clustering was used to identify the various LUAD molecular subtypes. A least absolute shrinkage and selection operator (LASSO) analysis was conducted to construct a prognostic signature.<h4>Results</h4>An 11-lncRNA prognostic signature out of 19 identified pyroptosis-related prognostic lncRNAs was constructed. The patients with LUAD were divided into low-risk and high-risk groups. Patients in the high-risk group had higher score values and mortality. The immune score, stromal score, and estimate score were lower in the high-risk group. The risk score was an independent predictor for OS in multivariate Cox regression analyses (HR > 1, p < 0.01). BTLA, PD-1, PD-L1, CTLA, and CD47 were lower expressed in the high-risk group.<h4>Conclusions</h4>Our study identified an 11-pyroptosis-related lncRNA signature. These findings could further clarify the role of pyroptosis in LUAD and guide the prognosis and individualized treatment of patients.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-06-18T08:50:51.116Z","creation":"2025-04-19T09:24:07.413Z"},"accession":"S-EPMC8924059","cross_references":{"pubmed":["35311148"],"doi":["10.3389/fonc.2022.850943"]}}