{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hernandez L"],"funding":["Austrian Science Fund FWF","Vetenskapsrådet","CIMED","Njurfonden","Hjärt-Lungfonden","ALF","Karolinska Institute"],"pagination":["4414"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8924178"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["Kidney failure and associated uraemia have implications for the cardiovascular system, brain, and blood-brain barrier (BBB). We aim to examine BBB disruption, by assessing brain-derived neurotropic factor (BDNF), neuron-specific enolase (NSE) levels, and gut-blood barrier (GBB) disruption by trimethylamine N-oxide (TMAO), in chronic kidney disease (CKD) patients. Additionally, endothelial tight-junction protein expressions and modulation via TMAO were assessed. Serum from chronic kidney disease (CKD) female and male haemodialysis (HD) patients, and controls, were used to measure BDNF and NSE by enzyme-linked immunosorbent assays, and TMAO by mass spectrometry. Immunofluorescent staining of subcutaneous fat biopsies from kidney transplant recipients, and controls, were used to measure micro"],"journal":["Scientific reports"],"pubmed_title":["Blood-brain barrier and gut barrier dysfunction in chronic kidney disease with a focus on circulating biomarkers and tight junction proteins."],"pmcid":["PMC8924178"],"funding_grant_id":["20160384","I 4209","2018-00932"],"pubmed_authors":["Kautzky-Willer A","Herrero MT","Heimburger O","Stenvinkel P","Arefin S","Laucyte-Cibulskiene A","Kublickiene K","Raparelli V","Wennberg L","Ebert T","Pilote L","Barany P","Hernandez L","Norris CM","Ward LJ","GOING-FWD Collaborators"],"additional_accession":[]},"is_claimable":false,"name":"Blood-brain barrier and gut barrier dysfunction in chronic kidney disease with a focus on circulating biomarkers and tight junction proteins.","description":"Kidney failure and associated uraemia have implications for the cardiovascular system, brain, and blood-brain barrier (BBB). We aim to examine BBB disruption, by assessing brain-derived neurotropic factor (BDNF), neuron-specific enolase (NSE) levels, and gut-blood barrier (GBB) disruption by trimethylamine N-oxide (TMAO), in chronic kidney disease (CKD) patients. Additionally, endothelial tight-junction protein expressions and modulation via TMAO were assessed. Serum from chronic kidney disease (CKD) female and male haemodialysis (HD) patients, and controls, were used to measure BDNF and NSE by enzyme-linked immunosorbent assays, and TMAO by mass spectrometry. Immunofluorescent staining of subcutaneous fat biopsies from kidney transplant recipients, and controls, were used to measure micro","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-26T18:32:15.938Z","creation":"2025-04-06T15:49:29.929Z"},"accession":"S-EPMC8924178","cross_references":{"pubmed":["35292710"],"doi":["10.1038/s41598-022-08387-7"]}}