biostudies-literatureKim JYNational Research Foundation of Korea (NRF)National Cancer CenterNational Cancer Center (NCC)Korea Health Industry Development InstituteNational Research Foundation of KoreaKorea Health Industry Development Institute (KHIDI)239https://www.ebi.ac.uk/biostudies/studies/S-EPMC8924236biostudies-literatureUnknown13(3)Ovarian carcinoma (OC) is the most lethal gynecological malignancy due to frequent recurrence resulting from cisplatin-resistance. ARL6IP5 is a novel gene implicated to suppress cisplatin-resistance by activating apoptosis and inhibiting DNA repair through XRCC1 and PARP1. We investigated the clinicopathological and prognostic significance of the immunohistochemical ARL6IP5 expression on 79 post-chemotherapy OC patient tissue samples; in vitro, the effect of ARL6IP5 overexpression (OE) and knockdown (KD) on cancer hallmark functions and the effect of ARL6IP5 on the expression of DNA repair and apoptosis-related proteins were observed in OC cells and their cisplatin-resistant (CisR) counterparts. ARL6IP5 expression was significantly associated with chemotherapeutic response and was an indepCell death & diseaseARL6IP5 reduces cisplatin-resistance by suppressing DNA repair and promoting apoptosis pathways in ovarian carcinoma.PMC89242362018R1C1B50437252016R1D1A1B039355842019R1FA1059148HI21C1137NCCCDA2018-04Yoon HKim SHKim JYBahar EKim HSPark EYDo SIChang SLee JYfalseARL6IP5 reduces cisplatin-resistance by suppressing DNA repair and promoting apoptosis pathways in ovarian carcinoma.Ovarian carcinoma (OC) is the most lethal gynecological malignancy due to frequent recurrence resulting from cisplatin-resistance. ARL6IP5 is a novel gene implicated to suppress cisplatin-resistance by activating apoptosis and inhibiting DNA repair through XRCC1 and PARP1. We investigated the clinicopathological and prognostic significance of the immunohistochemical ARL6IP5 expression on 79 post-chemotherapy OC patient tissue samples; in vitro, the effect of ARL6IP5 overexpression (OE) and knockdown (KD) on cancer hallmark functions and the effect of ARL6IP5 on the expression of DNA repair and apoptosis-related proteins were observed in OC cells and their cisplatin-resistant (CisR) counterparts. ARL6IP5 expression was significantly associated with chemotherapeutic response and was an indep2022-01-01T00:00:00Z2022 Mar2025-04-22T18:17:50.905Z2025-04-06T02:24:48.333ZS-EPMC89242363529338310.1038/s41419-022-04568-4