{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun C"],"funding":["Health and Family Planning Commission of Wuhan Municipality"],"pagination":["3421600"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8924609"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2022"],"pubmed_abstract":["Osteosarcoma is the most common primary malignant bone tumor in children and adolescents with poor prognosis. MicroRNA-181a-5p (miR-181a-5p) is involved in the progression of various tumors; however, its role and underlying mechanism in osteosarcoma remains unclear. In this study, we found that miR-181a-5p was upregulated in human osteosarcoma cells and tissues. miR-181a-5p mimic significantly promoted, while miR-181a-5p inhibitor blocked the proliferation, colony formation, migration, invasion, and cell cycle progression of osteosarcoma cells. Mechanistically, miR-181a-5p bound to the 3'-untranslational region of phosphatase and tensin homolog (PTEN) and reduced its protein expression, thereby activating protein kinase B (PKB/AKT) pathway. Either PTEN overexpression or AKT inhibition nota"],"journal":["Analytical cellular pathology (Amsterdam)"],"pubmed_title":["MicroRNA-181a-5p Promotes Osteosarcoma Progression via PTEN/AKT Pathway."],"pmcid":["PMC8924609"],"funding_grant_id":["WX19Q15"],"pubmed_authors":["Qian W","Ai F","Guo J","Xiao L","Chen Z","Guo X","Sun C","Yu ZH","Chen C"],"additional_accession":[]},"is_claimable":false,"name":"MicroRNA-181a-5p Promotes Osteosarcoma Progression via PTEN/AKT Pathway.","description":"Osteosarcoma is the most common primary malignant bone tumor in children and adolescents with poor prognosis. MicroRNA-181a-5p (miR-181a-5p) is involved in the progression of various tumors; however, its role and underlying mechanism in osteosarcoma remains unclear. In this study, we found that miR-181a-5p was upregulated in human osteosarcoma cells and tissues. miR-181a-5p mimic significantly promoted, while miR-181a-5p inhibitor blocked the proliferation, colony formation, migration, invasion, and cell cycle progression of osteosarcoma cells. Mechanistically, miR-181a-5p bound to the 3'-untranslational region of phosphatase and tensin homolog (PTEN) and reduced its protein expression, thereby activating protein kinase B (PKB/AKT) pathway. Either PTEN overexpression or AKT inhibition nota","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T03:53:52.028Z","creation":"2025-04-06T10:57:21.203Z"},"accession":"S-EPMC8924609","cross_references":{"pubmed":["35310933"],"doi":["10.1155/2022/3421600"]}}