biostudies-literatureReishofer D?sterreichische Forschungsf?rderungsgesellschaftEuropean Cooperation in Science and Technology1148-1157https://www.ebi.ac.uk/biostudies/studies/S-EPMC8924868biostudies-literatureUnknown23(3)Cellulose-water interactions are crucial to understand biological processes as well as to develop tailor made cellulose-based products. However, the main challenge to study these interactions is the diversity of natural cellulose fibers and alterations in their supramolecular structure. Here, we study the humidity response of different, well-defined, ultrathin cellulose films as a function of industrially relevant treatments using different techniques. As treatments, drying at elevated temperature, swelling, and swelling followed by drying at elevated temperatures were chosen. The cellulose films were prepared by spin coating a soluble cellulose derivative, trimethylsilyl cellulose, onto solid substrates followed by conversion to cellulose by HCl vapor. For the highest investigated humiditBiomacromoleculesHumidity Response of Cellulose Thin Films.PMC8924868FP1205842413Reishofer DPlank HFischer WJResel RSattelkow JMohan TTammelin TSpirk SAmenitsch HKontturi ENiegelhell KKleinschek KSfalseHumidity Response of Cellulose Thin Films.Cellulose-water interactions are crucial to understand biological processes as well as to develop tailor made cellulose-based products. However, the main challenge to study these interactions is the diversity of natural cellulose fibers and alterations in their supramolecular structure. Here, we study the humidity response of different, well-defined, ultrathin cellulose films as a function of industrially relevant treatments using different techniques. As treatments, drying at elevated temperature, swelling, and swelling followed by drying at elevated temperatures were chosen. The cellulose films were prepared by spin coating a soluble cellulose derivative, trimethylsilyl cellulose, onto solid substrates followed by conversion to cellulose by HCl vapor. For the highest investigated humidit2022-01-01T00:00:00Z2022 Mar2025-04-04T07:45:36.946Z2025-04-04T07:45:36.946ZS-EPMC89248683522559310.1021/acs.biomac.1c01446